Abstract
In the recent years immunological abnormalities, including defective polymorphonuclear neutrophils (PMN) chemotaxis and both quantitative and functional defects in T-lymphocytes, have been reported in atopic dermatitis (AD). To date there is still a controversy regarding the causes of PMN chemotaxis defect and the possible mechanism underlying this abnormality in patients with AD. The aim of this study was to investigate the PMN chemotactic function in 18 children affected with AD and high levels of serum IgE, and in 4 children with Hyper IgE Syndrome (HIES). Our results showed a marked PMN chemotaxis defect (p less than 0.01) in the patients with HIES, while in the subjects with AD PMN cellular chemotaxis was normal and there was no correlation between the results of chemotaxis and serum IgE levels.
| Original language | English |
|---|---|
| Pages (from-to) | 189-194 |
| Number of pages | 6 |
| Journal | Allergologia et Immunopathologia |
| Volume | 11 |
| Issue number | 3 |
| Publication status | Published - May 1983 |
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ASJC Scopus subject areas
- Immunology and Allergy
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IgE levels and PMN chemotaxis in atopic dermatitis. / Galli, E.; Rossi, P.; Fiore, L.; Perlini, R.; Celiboni, F.; Betti, P.; Businco, L.
In: Allergologia et Immunopathologia, Vol. 11, No. 3, 05.1983, p. 189-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IgE levels and PMN chemotaxis in atopic dermatitis.
AU - Galli, E.
AU - Rossi, P.
AU - Fiore, L.
AU - Perlini, R.
AU - Celiboni, F.
AU - Betti, P.
AU - Businco, L.
PY - 1983/5
Y1 - 1983/5
N2 - In the recent years immunological abnormalities, including defective polymorphonuclear neutrophils (PMN) chemotaxis and both quantitative and functional defects in T-lymphocytes, have been reported in atopic dermatitis (AD). To date there is still a controversy regarding the causes of PMN chemotaxis defect and the possible mechanism underlying this abnormality in patients with AD. The aim of this study was to investigate the PMN chemotactic function in 18 children affected with AD and high levels of serum IgE, and in 4 children with Hyper IgE Syndrome (HIES). Our results showed a marked PMN chemotaxis defect (p less than 0.01) in the patients with HIES, while in the subjects with AD PMN cellular chemotaxis was normal and there was no correlation between the results of chemotaxis and serum IgE levels.
AB - In the recent years immunological abnormalities, including defective polymorphonuclear neutrophils (PMN) chemotaxis and both quantitative and functional defects in T-lymphocytes, have been reported in atopic dermatitis (AD). To date there is still a controversy regarding the causes of PMN chemotaxis defect and the possible mechanism underlying this abnormality in patients with AD. The aim of this study was to investigate the PMN chemotactic function in 18 children affected with AD and high levels of serum IgE, and in 4 children with Hyper IgE Syndrome (HIES). Our results showed a marked PMN chemotaxis defect (p less than 0.01) in the patients with HIES, while in the subjects with AD PMN cellular chemotaxis was normal and there was no correlation between the results of chemotaxis and serum IgE levels.
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M3 - Article
C2 - 6605080
AN - SCOPUS:0020757865
VL - 11
SP - 189
EP - 194
JO - Allergologia et Immunopathologia
JF - Allergologia et Immunopathologia
SN - 0301-0546
IS - 3
ER -