IgE-mediated food allergy in children

Giorgio Longo, Irene Berti, A. Wesley Burks, Baruch Krauss, Egidio Barbi

Research output: Contribution to journalArticlepeer-review

Abstract

Food allergy is a serious health issue aff ecting roughly 4% of children, with a substantial eff ect on quality of life. Prognosis is good for the most frequent allergens with almost all children outgrowing their allergy. However, the long-term implications for disease burden are substantial for children with persistent allergies (eg, peanuts, tree nuts, fi sh, and shellfi sh) and for those with high concentrations of milk, egg, and wheat IgE. Antigen avoidance has been the time-honoured approach both for prevention and treatment. However, fi ndings from studies done in the past 5 years show that early contact with food can induce tolerance and desensitisation to foods. We review the epidemiology, natural history, and management of food allergy, and discuss the areas of controversy and future directions in research and clinical practice.

Original languageEnglish
Pages (from-to)1656-1664
Number of pages9
JournalLancet
Volume382
Issue number9905
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Medicine(all)

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