We explored the efficacy of the IGEV regimen (ifosfamide, gemcitabine, vinorelbine and prednisone) combined with a fixed dose of lenograstim (263μg/day) to mobilize peripheral blood stem cells (PBSCs) in 90 Hodgkin's lymphoma patients. The median total CD34+ cells/μl peak, colony-forming units granulocyte-macrophage and white blood cells for all individual collection sets were 85/μl, 12 × 10 4/ kg and 20 700/μl, respectively. An adequate number of CD34+ cells (more than 3 × 10 6 or 6 × 10 6 CD34+ cells/kg depending on whether single or tandem high-dose chemotherapy was used) were collected in 89 out of 90 (98.7%) mobilized patients, whereas the only failure reached 2.3 × 10 6 CD34+ cells/ kg. The median CD34+ cell collections were 11 × 10 6/kg (range 2.3-39 × 10 6/kg) and 10 × 10 6/ kg (range 6-22.0 × 10 6/kg) with a median of 1 and 2 leukaphereses for patients eligible for single high-dose treatment and for candidates for tandem transplant, respectively. Target yields were reached in 71.43 and 49.09% and additionally in 17.14 and 43.64% of cases after the first and second apheresis procedures, respectively. Hematological and non-hematological side effects were acceptable, and no toxic deaths occurred. Thirty-four patients received a single and 47 received tandem transplantation with rapid engraftment. These results confirm that the IGEV regimen with lenograstim support can be used successfully and safely to mobilize PBSCs.
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