IGF and POMC neuropeptides expression by neuroectodermal tumours

P. Guerrieri, G. Melino

Research output: Contribution to journalArticle

Abstract

During the last few decades many tumours have become available in tissue culture from different stages of progression and differentiation, including normal precursors and early malignant cells, enabling the delineation of the biological characteristics of the cells. These cells exhibit large differences in growth requirements, from complex media, such as serum, to defined conditioned media. Among the several growth factors identified so far, herein we shall attempt to outline two neuropeptides circuits, i.e. insulin-like growth factor (IGF) and proopiomelanocortin (POMC), and their role in the proliferation of neuroectodermal tumours.

Original languageEnglish
Pages (from-to)907-916
Number of pages10
JournalChronica Dermatologica
Volume3
Issue number6
Publication statusPublished - 1993

Keywords

  • IGF
  • melanoma
  • neural crest
  • neuroblastoma
  • neuropeptides
  • POMC

ASJC Scopus subject areas

  • Dermatology

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