IGF-I, IGFBP-3 and breast cancer in young women: A pooled re-analysis of three prospective studies

Sabina Rinaldi, Paolo Toniolo, Paola Muti, Eva Lundin, Anne Zeleniuch-Jacquotte, Alan Arslan, Andrea Micheli, Per Lenner, Laure Dossus, Vittorio Krogh, Roy E. Shore, Karen L. Koenig, Elio Riboli, Pär Stattin, Franco Berrino, Göran Hallmans, Annekatrin Lukanova, Rudolf Kaaks

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Umeå (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95% confidence intervals (95% CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.

Original languageEnglish
Pages (from-to)493-496
Number of pages4
JournalEuropean Journal of Cancer Prevention
Volume14
Issue number6
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Prospective Studies
Breast Neoplasms
Odds Ratio
Sweden
Italy
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Confidence Intervals

Keywords

  • Breast cancer
  • Cohort studies
  • Insulin-like growth factor binding protein 3
  • Insulin-like growth factor I

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rinaldi, S., Toniolo, P., Muti, P., Lundin, E., Zeleniuch-Jacquotte, A., Arslan, A., ... Kaaks, R. (2005). IGF-I, IGFBP-3 and breast cancer in young women: A pooled re-analysis of three prospective studies. European Journal of Cancer Prevention, 14(6), 493-496. https://doi.org/10.1097/00008469-200512000-00001

IGF-I, IGFBP-3 and breast cancer in young women : A pooled re-analysis of three prospective studies. / Rinaldi, Sabina; Toniolo, Paolo; Muti, Paola; Lundin, Eva; Zeleniuch-Jacquotte, Anne; Arslan, Alan; Micheli, Andrea; Lenner, Per; Dossus, Laure; Krogh, Vittorio; Shore, Roy E.; Koenig, Karen L.; Riboli, Elio; Stattin, Pär; Berrino, Franco; Hallmans, Göran; Lukanova, Annekatrin; Kaaks, Rudolf.

In: European Journal of Cancer Prevention, Vol. 14, No. 6, 12.2005, p. 493-496.

Research output: Contribution to journalArticle

Rinaldi, S, Toniolo, P, Muti, P, Lundin, E, Zeleniuch-Jacquotte, A, Arslan, A, Micheli, A, Lenner, P, Dossus, L, Krogh, V, Shore, RE, Koenig, KL, Riboli, E, Stattin, P, Berrino, F, Hallmans, G, Lukanova, A & Kaaks, R 2005, 'IGF-I, IGFBP-3 and breast cancer in young women: A pooled re-analysis of three prospective studies', European Journal of Cancer Prevention, vol. 14, no. 6, pp. 493-496. https://doi.org/10.1097/00008469-200512000-00001
Rinaldi, Sabina ; Toniolo, Paolo ; Muti, Paola ; Lundin, Eva ; Zeleniuch-Jacquotte, Anne ; Arslan, Alan ; Micheli, Andrea ; Lenner, Per ; Dossus, Laure ; Krogh, Vittorio ; Shore, Roy E. ; Koenig, Karen L. ; Riboli, Elio ; Stattin, Pär ; Berrino, Franco ; Hallmans, Göran ; Lukanova, Annekatrin ; Kaaks, Rudolf. / IGF-I, IGFBP-3 and breast cancer in young women : A pooled re-analysis of three prospective studies. In: European Journal of Cancer Prevention. 2005 ; Vol. 14, No. 6. pp. 493-496.
@article{5f0ecfc801e047cba86ae60324060b16,
title = "IGF-I, IGFBP-3 and breast cancer in young women: A pooled re-analysis of three prospective studies",
abstract = "Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Ume{\aa} (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95{\%} confidence intervals (95{\%} CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.",
keywords = "Breast cancer, Cohort studies, Insulin-like growth factor binding protein 3, Insulin-like growth factor I",
author = "Sabina Rinaldi and Paolo Toniolo and Paola Muti and Eva Lundin and Anne Zeleniuch-Jacquotte and Alan Arslan and Andrea Micheli and Per Lenner and Laure Dossus and Vittorio Krogh and Shore, {Roy E.} and Koenig, {Karen L.} and Elio Riboli and P{\"a}r Stattin and Franco Berrino and G{\"o}ran Hallmans and Annekatrin Lukanova and Rudolf Kaaks",
year = "2005",
month = "12",
doi = "10.1097/00008469-200512000-00001",
language = "English",
volume = "14",
pages = "493--496",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - IGF-I, IGFBP-3 and breast cancer in young women

T2 - A pooled re-analysis of three prospective studies

AU - Rinaldi, Sabina

AU - Toniolo, Paolo

AU - Muti, Paola

AU - Lundin, Eva

AU - Zeleniuch-Jacquotte, Anne

AU - Arslan, Alan

AU - Micheli, Andrea

AU - Lenner, Per

AU - Dossus, Laure

AU - Krogh, Vittorio

AU - Shore, Roy E.

AU - Koenig, Karen L.

AU - Riboli, Elio

AU - Stattin, Pär

AU - Berrino, Franco

AU - Hallmans, Göran

AU - Lukanova, Annekatrin

AU - Kaaks, Rudolf

PY - 2005/12

Y1 - 2005/12

N2 - Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Umeå (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95% confidence intervals (95% CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.

AB - Prospective cohort studies on breast cancer risk among premenopausal women and insulin-like growth factor I (IGF-I) concentrations have so far included only few cases, and have shown inconsistent relative risk estimates. We pooled 220 cases of breast cancer diagnosed before age 50, and 434 control subjects, from three prospective studies in New York (USA), Umeå (Northern Sweden) and Milan (Italy), and we measured IGF-I and insulin-like growth factor binding protein 3 (IGFBP-3) with common enzyme-linked immunosorbent assays. Overall, IGF-I and IGFBP-3 measurements obtained by the common method showed a positive but not significant relationship with breast cancer risk (odds ratios (ORs) 0.90 [95% confidence intervals (95% CI) 0.50-1.62], 1.63 [0.89-2.97], 1.46 [0.78-2.73] and 1.41 [0.75-2.63] for quintiles of IGF-I, and ORs 0.98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women.

KW - Breast cancer

KW - Cohort studies

KW - Insulin-like growth factor binding protein 3

KW - Insulin-like growth factor I

UR - http://www.scopus.com/inward/record.url?scp=28044443343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28044443343&partnerID=8YFLogxK

U2 - 10.1097/00008469-200512000-00001

DO - 10.1097/00008469-200512000-00001

M3 - Article

C2 - 16284492

AN - SCOPUS:28044443343

VL - 14

SP - 493

EP - 496

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

IS - 6

ER -