IGF-I regulates caveolin 1 and IRS1 interaction in caveolae

Danilo Panetta, Claudia Biedi, Silvia Repetto, Renzo Cordera, Davide Maggi

Research output: Contribution to journalArticlepeer-review

Abstract

Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume316
Issue number1
DOIs
Publication statusPublished - Mar 26 2004

Keywords

  • Caveolin 1
  • IGF-I receptor
  • IRS1
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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