IGF-I regulates caveolin 1 and IRS1 interaction in caveolae

Danilo Panetta; Claudia Biedi; Silvia Repetto; Renzo Cordera; Davide Maggi

doi:10.1016/j.bbrc.2004.02.037

IGF-I regulates caveolin 1 and IRS1 interaction in caveolae

Danilo Panetta, Claudia Biedi, Silvia Repetto, Renzo Cordera, Davide Maggi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	316
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.02.037
Publication status	Published - Mar 26 2004

Keywords

Caveolin 1
IGF-I receptor
IRS1
Tyrosine phosphorylation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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abstract = "Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I.",

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AU - Panetta, Danilo

AU - Biedi, Claudia

AU - Repetto, Silvia

AU - Cordera, Renzo

AU - Maggi, Davide

PY - 2004/3/26

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AB - Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I.

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KW - IGF-I receptor

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