TY - JOUR
T1 - IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth
AU - Melino, Gennaro
AU - Stephanou, Anastasis
AU - Annicchiarico-Petruzzelli, Margherita
AU - Finazzi-Agró, Alessandro
AU - Knight, Richard A.
AU - Lightman, Stafford L.
PY - 1992/9/14
Y1 - 1992/9/14
N2 - A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.
AB - A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.
KW - Glioblastoma
KW - Growth hormone-releasing hormone
KW - Insulin-like growth factor-II
KW - Retinoic acid
KW - α-Difluoromethylornithine
UR - http://www.scopus.com/inward/record.url?scp=0026744076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026744076&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(92)90707-E
DO - 10.1016/0304-3940(92)90707-E
M3 - Article
C2 - 1436709
AN - SCOPUS:0026744076
VL - 144
SP - 25
EP - 28
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -