IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth

Gennaro Melino; Anastasis Stephanou; Margherita Annicchiarico-Petruzzelli; Alessandro Finazzi-Agró; Richard A. Knight; Stafford L. Lightman

doi:10.1016/0304-3940(92)90707-E

IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth

Gennaro Melino, Anastasis Stephanou, Margherita Annicchiarico-Petruzzelli, Alessandro Finazzi-Agró, Richard A. Knight, Stafford L. Lightman

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article

Abstract

A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	144
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(92)90707-E
Publication status	Published - Sep 14 1992

Keywords

Glioblastoma
Growth hormone-releasing hormone
Insulin-like growth factor-II
Retinoic acid
α-Difluoromethylornithine

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(92)90707-E

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Melino, G., Stephanou, A., Annicchiarico-Petruzzelli, M., Finazzi-Agró, A., Knight, R. A., & Lightman, S. L. (1992). IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth. Neuroscience Letters, 144(1-2), 25-28. https://doi.org/10.1016/0304-3940(92)90707-E

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title = "IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth",

abstract = "A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.",

keywords = "Glioblastoma, Growth hormone-releasing hormone, Insulin-like growth factor-II, Retinoic acid, α-Difluoromethylornithine",

author = "Gennaro Melino and Anastasis Stephanou and Margherita Annicchiarico-Petruzzelli and Alessandro Finazzi-Agr{\'o} and Knight, {Richard A.} and Lightman, {Stafford L.}",

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AU - Melino, Gennaro

AU - Stephanou, Anastasis

AU - Annicchiarico-Petruzzelli, Margherita

AU - Finazzi-Agró, Alessandro

AU - Knight, Richard A.

AU - Lightman, Stafford L.

PY - 1992/9/14

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N2 - A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.

AB - A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.

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KW - Retinoic acid

KW - α-Difluoromethylornithine

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