IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth

Gennaro Melino, Anastasis Stephanou, Margherita Annicchiarico-Petruzzelli, Alessandro Finazzi-Agró, Richard A. Knight, Stafford L. Lightman

Research output: Contribution to journalArticlepeer-review


A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - Sep 14 1992


  • Glioblastoma
  • Growth hormone-releasing hormone
  • Insulin-like growth factor-II
  • Retinoic acid
  • α-Difluoromethylornithine

ASJC Scopus subject areas

  • Neuroscience(all)


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