Abstract
Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic profile in adults. We performed the molecular screening of two IGF2 polymorphisms (6815 A/T, 820 G/A), in 227 obese children to evaluate the potential association between IGF2 variants with either obesity or high blood pressure (assessed with a 24-h holter system) or both. A second cohort of age-, sex-, and BMI-matched children were enrolled to confirm any eventual association. We observed a significant association between the 6815 A/T IGF2 gene variant and high systolic blood pressure in obese children. Homozygote subjects for the T6815 allele showed, even in 24-h measurements, a higher risk to develop hypertension than those carrying the A6815 allele (OR = 3.7, 95% CI: 1.59-8.66). This result was confirmed in the second cohort (OR = 4.1, 95% CI: 1.41-6.50). Any statistically significant difference in terms of BMI between the genotype groups was observed. Our results suggest that IGF2 gene variants are involved in the blood pressure regulation in obese children.
| Original language | English |
|---|---|
| Pages (from-to) | 340-344 |
| Number of pages | 5 |
| Journal | Pediatric Research |
| Volume | 67 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2010 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Medicine(all)
Cite this
IGF2 gene variants and risk of hypertension in obese children and adolescents. / Faienza, Maria F.; Santoro, Nicola; Lauciello, Rosaria; Calabró, Raffaele; Giordani, Lucia; Di Salvo, Giovanni; Ventura, Annamaria; Delvecchio, Maurizio; Perrone, Laura; Del Giudice, Emanuele M.; Cavallo, Luciano.
In: Pediatric Research, Vol. 67, No. 4, 2010, p. 340-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IGF2 gene variants and risk of hypertension in obese children and adolescents
AU - Faienza, Maria F.
AU - Santoro, Nicola
AU - Lauciello, Rosaria
AU - Calabró, Raffaele
AU - Giordani, Lucia
AU - Di Salvo, Giovanni
AU - Ventura, Annamaria
AU - Delvecchio, Maurizio
AU - Perrone, Laura
AU - Del Giudice, Emanuele M.
AU - Cavallo, Luciano
PY - 2010
Y1 - 2010
N2 - Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic profile in adults. We performed the molecular screening of two IGF2 polymorphisms (6815 A/T, 820 G/A), in 227 obese children to evaluate the potential association between IGF2 variants with either obesity or high blood pressure (assessed with a 24-h holter system) or both. A second cohort of age-, sex-, and BMI-matched children were enrolled to confirm any eventual association. We observed a significant association between the 6815 A/T IGF2 gene variant and high systolic blood pressure in obese children. Homozygote subjects for the T6815 allele showed, even in 24-h measurements, a higher risk to develop hypertension than those carrying the A6815 allele (OR = 3.7, 95% CI: 1.59-8.66). This result was confirmed in the second cohort (OR = 4.1, 95% CI: 1.41-6.50). Any statistically significant difference in terms of BMI between the genotype groups was observed. Our results suggest that IGF2 gene variants are involved in the blood pressure regulation in obese children.
AB - Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic profile in adults. We performed the molecular screening of two IGF2 polymorphisms (6815 A/T, 820 G/A), in 227 obese children to evaluate the potential association between IGF2 variants with either obesity or high blood pressure (assessed with a 24-h holter system) or both. A second cohort of age-, sex-, and BMI-matched children were enrolled to confirm any eventual association. We observed a significant association between the 6815 A/T IGF2 gene variant and high systolic blood pressure in obese children. Homozygote subjects for the T6815 allele showed, even in 24-h measurements, a higher risk to develop hypertension than those carrying the A6815 allele (OR = 3.7, 95% CI: 1.59-8.66). This result was confirmed in the second cohort (OR = 4.1, 95% CI: 1.41-6.50). Any statistically significant difference in terms of BMI between the genotype groups was observed. Our results suggest that IGF2 gene variants are involved in the blood pressure regulation in obese children.
UR - http://www.scopus.com/inward/record.url?scp=77949556927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949556927&partnerID=8YFLogxK
U2 - 10.1203/PDR.0b013e3181d22757
DO - 10.1203/PDR.0b013e3181d22757
M3 - Article
VL - 67
SP - 340
EP - 344
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 4
ER -