Abstract
Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.
Original language | English |
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Pages (from-to) | 77-80 |
Number of pages | 4 |
Journal | Journal of Neuroimmunology |
Volume | 58 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Acute motor neuropathy
- Anti-asialo GM1 antibody
- Anti-GMl antibody
- Guillain-Barré syndrome
- Immunoglobulin G subclass
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology