IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses

Mieko Ogino, Nobile Orazio, Norman Latov

Research output: Contribution to journalArticlepeer-review

Abstract

Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalJournal of Neuroimmunology
Volume58
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • Acute motor neuropathy
  • Anti-asialo GM1 antibody
  • Anti-GMl antibody
  • Guillain-Barré syndrome
  • Immunoglobulin G subclass

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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