IGG practice guidelines on germ cell tumor in adult male patients

Ugo De Giorgi, Nicola Nicolai, Silvia Tana, Ivan Matteo Tavolini, Silvia Palazzi, Sergio Bracarda, Lucilla Tedeschi, Giovannella Palmieri, Luca Frassineti, Luigi Da Pozzo, Ugo Pastorino, Ermanno Emiliani, Maurizio Marangolo, Giorgio Pizzocaro, Giovanni Rosti, Roberto Salvioni

Research output: Contribution to journalArticlepeer-review


Germ cell tumors are rare neoplasms that affect young males. Nearly 99% of patients with localized stage I disease and nearly 80% of patients with metastatic disease can be cured. Even patients who relapse following chemotherapy can achieve a long-term survival in approximately 30-40% of cases. The main objective in early stages and in good prognosis patients has changed in recent years, and it has become of major importance to reduce treatment-related morbidity without compromising the excellent long-term survival rate. In poor prognosis patients, there is a correlation between the experience of the treating institution and the long-term clinical outcome of the patients, particularly when the most sophisticated therapies are needed. So far, of utmost importance is the information from updated practice guidelines for the diagnosis and treatment of germ cell tumors. The Italian Germ cell cancer Group (IGG) has developed the following clinical recommendations, which identify me current standards in diagnosis and treatment of germ cell tumors in adult males.

Original languageEnglish
Pages (from-to)96-109
Number of pages14
Issue number1
Publication statusPublished - Jan 2008


  • Germ cell tumor
  • Guidelines
  • Non-seminoma
  • Seminoma
  • Testicular cancer

ASJC Scopus subject areas

  • Cancer Research


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