IgG subclass deficiency in patients with Down's syndrome and aberrant hepatitis B vaccine response

M. A. Avanzini, T. Soderstrom, M. Wahl, A. Plebani, G. R. Burgio, L. A. Hanson

Research output: Contribution to journalArticle

Abstract

Seventeen adult patients with Down's syndrome (DS) and 19 adult healthy references were vaccinated with a hepatitis B vaccine in order to study the IgG subclass response. An enzyme-linked immunosorbent assay (ELISA) using monoclonal antibodies specific for IgG subclasses was employed. In spite of normal levels of total IgG1 and normal or even high levels of IgG3 in the DS patients, a significantly lower IgG1 response to the vaccine was observed in trisomic patients than in the references.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalScandinavian Journal of Immunology
Volume28
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

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    Avanzini, M. A., Soderstrom, T., Wahl, M., Plebani, A., Burgio, G. R., & Hanson, L. A. (1988). IgG subclass deficiency in patients with Down's syndrome and aberrant hepatitis B vaccine response. Scandinavian Journal of Immunology, 28(4), 465-470.