Abstract
Immunoglobulin G4-related diseases (IgG4-RD) are a group of chronic relapsing-remitting inflammatory conditions, characterised by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, fibrosis and a usually favourable response to steroids. In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the European Reference Network ReCONNET, aimed at evaluating existing clinical practice guidelines (CPGs) and recommendations in IgG4-RD. From 167 publications initially obtained from a systematic literature search, only one was identified as a systematic multispecialist, evidence-based, consensus guidance statement on diagnosis and treatment of IgG4-RD, which may be recommended for use as CPG in IgG4-RD. With the recognition of a limited evidence based in this increasingly recognised disease, the group discussion has identified the following unmet needs: lack of shared classification criteria, absence of formal guidelines on diagnosis, no evidence-based therapeutic recommendations and lack of activity and damage indices. Areas of unmet needs include the difficulties in diagnosis, management and monitoring and the scarcity of expert centres.
| Original language | English |
|---|---|
| Article number | e000787 |
| Journal | RMD Open |
| Volume | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
Fingerprint
Keywords
- clinical practice guidelines
- ERN reconnet
- european reference networks
- IgG4-related diseases
- unmet needs
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
Cite this
IgG4-related diseases : State of the art on clinical practice guidelines. / Iaccarino, Luca; Talarico, Rosaria; Scirè, Carlo Alberto; Amoura, Zahir; Burmester, Gerd; Doria, Andrea; Faiz, Karim; Frank, Charissa; Hachulla, Eric; Hie, Miguel; Launay, David; Montecucco, Carlomaurizio; Monti, Sara; Mouthon, Luc; Tincani, Angela; Toniati, Paola; Van Hagen, Pieter Martin; Van Vollenhoven, Ronald F.; Bombardieri, Stefano; Mueller-Ladner, Ulf; Schneider, Matthias; Smith, Vanessa; Cutolo, Maurizio; Mosca, Marta; Alexander, Tobias.
In: RMD Open, Vol. 4, e000787, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - IgG4-related diseases
T2 - State of the art on clinical practice guidelines
AU - Iaccarino, Luca
AU - Talarico, Rosaria
AU - Scirè, Carlo Alberto
AU - Amoura, Zahir
AU - Burmester, Gerd
AU - Doria, Andrea
AU - Faiz, Karim
AU - Frank, Charissa
AU - Hachulla, Eric
AU - Hie, Miguel
AU - Launay, David
AU - Montecucco, Carlomaurizio
AU - Monti, Sara
AU - Mouthon, Luc
AU - Tincani, Angela
AU - Toniati, Paola
AU - Van Hagen, Pieter Martin
AU - Van Vollenhoven, Ronald F.
AU - Bombardieri, Stefano
AU - Mueller-Ladner, Ulf
AU - Schneider, Matthias
AU - Smith, Vanessa
AU - Cutolo, Maurizio
AU - Mosca, Marta
AU - Alexander, Tobias
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Immunoglobulin G4-related diseases (IgG4-RD) are a group of chronic relapsing-remitting inflammatory conditions, characterised by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, fibrosis and a usually favourable response to steroids. In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the European Reference Network ReCONNET, aimed at evaluating existing clinical practice guidelines (CPGs) and recommendations in IgG4-RD. From 167 publications initially obtained from a systematic literature search, only one was identified as a systematic multispecialist, evidence-based, consensus guidance statement on diagnosis and treatment of IgG4-RD, which may be recommended for use as CPG in IgG4-RD. With the recognition of a limited evidence based in this increasingly recognised disease, the group discussion has identified the following unmet needs: lack of shared classification criteria, absence of formal guidelines on diagnosis, no evidence-based therapeutic recommendations and lack of activity and damage indices. Areas of unmet needs include the difficulties in diagnosis, management and monitoring and the scarcity of expert centres.
AB - Immunoglobulin G4-related diseases (IgG4-RD) are a group of chronic relapsing-remitting inflammatory conditions, characterised by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, fibrosis and a usually favourable response to steroids. In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the European Reference Network ReCONNET, aimed at evaluating existing clinical practice guidelines (CPGs) and recommendations in IgG4-RD. From 167 publications initially obtained from a systematic literature search, only one was identified as a systematic multispecialist, evidence-based, consensus guidance statement on diagnosis and treatment of IgG4-RD, which may be recommended for use as CPG in IgG4-RD. With the recognition of a limited evidence based in this increasingly recognised disease, the group discussion has identified the following unmet needs: lack of shared classification criteria, absence of formal guidelines on diagnosis, no evidence-based therapeutic recommendations and lack of activity and damage indices. Areas of unmet needs include the difficulties in diagnosis, management and monitoring and the scarcity of expert centres.
KW - clinical practice guidelines
KW - ERN reconnet
KW - european reference networks
KW - IgG4-related diseases
KW - unmet needs
UR - http://www.scopus.com/inward/record.url?scp=85060282316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060282316&partnerID=8YFLogxK
U2 - 10.1136/rmdopen-2018-000787
DO - 10.1136/rmdopen-2018-000787
M3 - Review article
AN - SCOPUS:85060282316
VL - 4
JO - RMD Open
JF - RMD Open
SN - 2056-5933
M1 - e000787
ER -