The diagnostic of cartilaginous tumours, especially the decision of dignity, is often still difficult. Therefore we investigated 92 cartilaginous tumours, well separated in multiple and solitary osteochondromas, enchondromas, peripheral chondrosarcomas with and without history of hereditary osteochondromas and central chondrosarcomas of different grades as well as dedifferentiated chondrosarcomas for the immunohistochemical expression of Indian Hedgehog, Parathyroidhormone related peptide and the Bone morphogenetic protein receptors type Ia, Ib and II. Those signaling proteins seem to play an important role in the developement of normal chondrocytic differentiation and were therefore regarded as putative diagnostic markers of the progression towards malignancy in chondroid tumours. Results showed excellent distinction of osteochondromas verse chondrosarcomas by expression of Indian Hedgehog protein (4.9% verse 54.1%) and BMPR-II (5.1% verse 48.3%). In central cartilaginous tumors we found surprisingly quite high expression of all investigated markers even in enchondromas. We could observe an increasing percentage in higher grades of malignity. Dedifferentiated chondrosarcomas showed in all cases complete strong immunoreaction of all investigated antibodies. The expression of BMPR-IB (25% verse 60%) gave clear distinction between enchondromas and grade I chondrosarcomas.
- Bone morphogenetic protein receptors
- Cartilaginous tumours
- Indian Hedgehog
ASJC Scopus subject areas