II. - 5-Fluorouracil, twenty-five years later. An appraisal

F. Boccardo, L. Canobbio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.

Original languageEnglish
Pages (from-to)180-189
Number of pages10
JournalChemioterapia
Volume2
Issue number3
Publication statusPublished - 1983

Fingerprint

Fluorouracil
Liver
Drug-Related Side Effects and Adverse Reactions
Cervix Uteri
Colonic Neoplasms
Pancreas
Ovary
Neoplasms
Stomach
Breast
Perfusion
Carcinoma
Lung
Research
Pharmaceutical Preparations
Therapeutics
Pancreatic Carcinoma

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

II. - 5-Fluorouracil, twenty-five years later. An appraisal. / Boccardo, F.; Canobbio, L.

In: Chemioterapia, Vol. 2, No. 3, 1983, p. 180-189.

Research output: Contribution to journalArticle

Boccardo, F. ; Canobbio, L. / II. - 5-Fluorouracil, twenty-five years later. An appraisal. In: Chemioterapia. 1983 ; Vol. 2, No. 3. pp. 180-189.
@article{08892ef7652b4507b5365533604b91f4,
title = "II. - 5-Fluorouracil, twenty-five years later. An appraisal",
abstract = "The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.",
author = "F. Boccardo and L. Canobbio",
year = "1983",
language = "English",
volume = "2",
pages = "180--189",
journal = "Chemioterapia",
issn = "0392-906X",
publisher = "Editrice Giuntina",
number = "3",

}

TY - JOUR

T1 - II. - 5-Fluorouracil, twenty-five years later. An appraisal

AU - Boccardo, F.

AU - Canobbio, L.

PY - 1983

Y1 - 1983

N2 - The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.

AB - The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.

UR - http://www.scopus.com/inward/record.url?scp=0020960536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020960536&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0020960536

VL - 2

SP - 180

EP - 189

JO - Chemioterapia

JF - Chemioterapia

SN - 0392-906X

IS - 3

ER -