II. - 5-Fluorouracil, twenty-five years later. An appraisal

F. Boccardo, L. Canobbio

Research output: Contribution to journalArticlepeer-review


The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.

Original languageEnglish
Pages (from-to)180-189
Number of pages10
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)


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