Abstract
The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 180-189 |
| Number of pages | 10 |
| Journal | Chemioterapia |
| Volume | 2 |
| Issue number | 3 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
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II. - 5-Fluorouracil, twenty-five years later. An appraisal. / Boccardo, F.; Canobbio, L.
In: Chemioterapia, Vol. 2, No. 3, 1983, p. 180-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - II. - 5-Fluorouracil, twenty-five years later. An appraisal
AU - Boccardo, F.
AU - Canobbio, L.
PY - 1983
Y1 - 1983
N2 - The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.
AB - The second part of this review will analyze the results achieved by treatment with 5-fluorouracil alone or in combination regimens in stomach, pancreas, liver, breast, lung, ovary and cervix carcinomas. Attention will also be focused on particular therapeutic modalities such as loco-regional perfusion of liver, primary and metastatic neoplasms, and combined radiochemotherapeutic management of pancreatic carcinoma. From this review, it appears that 5-fluorouracil as a single agent still represents the standard treatment for large bowel cancer and is a basic component of the combination regimens which provide increasingly successful control for the majority of solid tumors. As there is evidence that proper scheduling of the drug, which produces a mild toxicity, is required to achieve the best results at least in some instances, further research on possible ways to enhance 5-Fu activity and reduce drug-induced toxicity is warranted.
UR - http://www.scopus.com/inward/record.url?scp=0020960536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020960536&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0020960536
VL - 2
SP - 180
EP - 189
JO - Chemioterapia
JF - Chemioterapia
SN - 0392-906X
IS - 3
ER -