IKK connects autophagy to major stress pathways

Alfredo Criollo; Laura Senovilla; Hélène Authier; Maria Chiara Maiuri; Eugenia Morselli; Ilio Vitale; Oliver Kepp; Ezgi Tasdemir; Lorenzo Galluzzi; Si Shen; Maximilien Tailler; Nicolas Delahaye; Antoine Tesniere; Daniela De Stefano; Aména Ben Younes; Francis Harper; Gérard Pierron; Sergio Lavandero; Laurence Zitvoge; Alain Israel; Véronique Baud; Guido Kroemer

doi:10.4161/auto.6.1.10818

IKK connects autophagy to major stress pathways

Alfredo Criollo, Laura Senovilla, Hélène Authier, Maria Chiara Maiuri, Eugenia Morselli, Ilio Vitale, Oliver Kepp, Ezgi Tasdemir, Lorenzo Galluzzi, Si Shen, Maximilien Tailler, Nicolas Delahaye, Antoine Tesniere, Daniela De Stefano, Aména Ben Younes, Francis Harper, Gérard Pierron, Sergio Lavandero, Laurence Zitvoge, Alain IsraelVéronique Baud, Guido Kroemer

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Autophagy
Volume	6
Issue number	1
DOIs	https://doi.org/10.4161/auto.6.1.10818
Publication status	Published - Jan 1 2010

Keywords

AMPK
JNK1
mTOR
Nutrient deprivation
Rapamycin

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.4161/auto.6.1.10818

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Criollo, A., Senovilla, L., Authier, H., Maiuri, M. C., Morselli, E., Vitale, I., Kepp, O., Tasdemir, E., Galluzzi, L., Shen, S., Tailler, M., Delahaye, N., Tesniere, A., De Stefano, D., Younes, A. B., Harper, F., Pierron, G., Lavandero, S., Zitvoge, L., ... Kroemer, G. (2010). IKK connects autophagy to major stress pathways. Autophagy, 6(1), 189-191. https://doi.org/10.4161/auto.6.1.10818

IKK connects autophagy to major stress pathways. / Criollo, Alfredo; Senovilla, Laura; Authier, Hélène; Maiuri, Maria Chiara; Morselli, Eugenia; Vitale, Ilio; Kepp, Oliver; Tasdemir, Ezgi; Galluzzi, Lorenzo; Shen, Si; Tailler, Maximilien; Delahaye, Nicolas; Tesniere, Antoine; De Stefano, Daniela; Younes, Aména Ben; Harper, Francis; Pierron, Gérard; Lavandero, Sergio; Zitvoge, Laurence; Israel, Alain; Baud, Véronique; Kroemer, Guido.

In: Autophagy, Vol. 6, No. 1, 01.01.2010, p. 189-191.

Research output: Contribution to journal › Article › peer-review

Criollo, A, Senovilla, L, Authier, H, Maiuri, MC, Morselli, E, Vitale, I, Kepp, O, Tasdemir, E, Galluzzi, L, Shen, S, Tailler, M, Delahaye, N, Tesniere, A, De Stefano, D, Younes, AB, Harper, F, Pierron, G, Lavandero, S, Zitvoge, L, Israel, A, Baud, V & Kroemer, G 2010, 'IKK connects autophagy to major stress pathways', Autophagy, vol. 6, no. 1, pp. 189-191. https://doi.org/10.4161/auto.6.1.10818

Criollo, Alfredo ; Senovilla, Laura ; Authier, Hélène ; Maiuri, Maria Chiara ; Morselli, Eugenia ; Vitale, Ilio ; Kepp, Oliver ; Tasdemir, Ezgi ; Galluzzi, Lorenzo ; Shen, Si ; Tailler, Maximilien ; Delahaye, Nicolas ; Tesniere, Antoine ; De Stefano, Daniela ; Younes, Aména Ben ; Harper, Francis ; Pierron, Gérard ; Lavandero, Sergio ; Zitvoge, Laurence ; Israel, Alain ; Baud, Véronique ; Kroemer, Guido. / IKK connects autophagy to major stress pathways. In: Autophagy. 2010 ; Vol. 6, No. 1. pp. 189-191.

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IKK connects autophagy to major stress pathways

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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