Abstract
Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.
Original language | English |
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Pages (from-to) | 189-191 |
Number of pages | 3 |
Journal | Autophagy |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 2010 |
Keywords
- AMPK
- JNK1
- mTOR
- Nutrient deprivation
- Rapamycin
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology