IL-1 alpha, IL-1 beta and psoriasis

Conflicting results in the literature. Opposite behaviour of the two cytokines in lesional or non-lesional extracts of whole skin

C. Bonifati, M. Carduccf, A. Mussi, L. D'Auria, F. Ameglio

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Abstract

A still debated question in the field of the cytokine network in psoriasis is represented by contrasting data reported on the local amount of IL-1 in this dermatosis. In fact previous studies have suggested that there were decreased IL-1 alpha amounts at the lesional level but increased non-functional IL-1 beta concentrations as compared to the non-lesional and normal epidermis. However, recent data suggest that IL-1 alpha and to a lesser extent, IL-1 beta amounts, are both increased and biologically active in the epidermal cell suspension of lesional psoriatic skin as compared to those of normal skin. The data reported in the present paper show that IL-1 alpha levels are decreased in psoriatic lesional extracts of whole skin (mean 2.9 ± 2 pg/mg) as compared to non-lesional (mean 6.7 ± 6.2 mg/mg, p = 0.02) or normal skin (mean 13.8 ± 9.4 pg/mg; p = 0.0002). IL-1 alpha concentrations were also significantly lower in the non-lesional skin than in normal skin (p = 0.02). In contrast, the IL-1 beta levels (mean 1.2 ± 0.74 pg/mg) were higher in the lesional samples than in the non-lesional ones (mean 0.5 ± 0.4 pg/mg, p = 0.004) or in normal skin (mean 0.4 ± 0.2 pg/mg, p = 0.004). No differences in IL-1 beta levels were observed between non-lesional and normal skin (p = 0.3). In addition both IL-1 alpha and IL-1 beta are directly correlated with the disease severity and each other. Our data, extending the IL-1 determination to the whole skin, seem to confirm the previously reported findings at the epidermis level and provide new light on possible interpretation of literature discrepancies.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume11
Issue number4
Publication statusPublished - Oct 1997

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psoriasis
Interleukin-1alpha
interleukin-1
Interleukin-1beta
Psoriasis
cytokines
Cytokines
Skin
extracts
Interleukin-1
Epidermis
Skin Diseases
Suspensions
skin diseases
disease severity
cell suspension culture
Light

Keywords

  • IL-1 alpha
  • IL-1 beta
  • Plaque-type psoriasis
  • Skin extract

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

@article{91843154d455415eaa2c92609f1ca9c3,
title = "IL-1 alpha, IL-1 beta and psoriasis: Conflicting results in the literature. Opposite behaviour of the two cytokines in lesional or non-lesional extracts of whole skin",
abstract = "A still debated question in the field of the cytokine network in psoriasis is represented by contrasting data reported on the local amount of IL-1 in this dermatosis. In fact previous studies have suggested that there were decreased IL-1 alpha amounts at the lesional level but increased non-functional IL-1 beta concentrations as compared to the non-lesional and normal epidermis. However, recent data suggest that IL-1 alpha and to a lesser extent, IL-1 beta amounts, are both increased and biologically active in the epidermal cell suspension of lesional psoriatic skin as compared to those of normal skin. The data reported in the present paper show that IL-1 alpha levels are decreased in psoriatic lesional extracts of whole skin (mean 2.9 ± 2 pg/mg) as compared to non-lesional (mean 6.7 ± 6.2 mg/mg, p = 0.02) or normal skin (mean 13.8 ± 9.4 pg/mg; p = 0.0002). IL-1 alpha concentrations were also significantly lower in the non-lesional skin than in normal skin (p = 0.02). In contrast, the IL-1 beta levels (mean 1.2 ± 0.74 pg/mg) were higher in the lesional samples than in the non-lesional ones (mean 0.5 ± 0.4 pg/mg, p = 0.004) or in normal skin (mean 0.4 ± 0.2 pg/mg, p = 0.004). No differences in IL-1 beta levels were observed between non-lesional and normal skin (p = 0.3). In addition both IL-1 alpha and IL-1 beta are directly correlated with the disease severity and each other. Our data, extending the IL-1 determination to the whole skin, seem to confirm the previously reported findings at the epidermis level and provide new light on possible interpretation of literature discrepancies.",
keywords = "IL-1 alpha, IL-1 beta, Plaque-type psoriasis, Skin extract",
author = "C. Bonifati and M. Carduccf and A. Mussi and L. D'Auria and F. Ameglio",
year = "1997",
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T2 - Conflicting results in the literature. Opposite behaviour of the two cytokines in lesional or non-lesional extracts of whole skin

AU - Bonifati, C.

AU - Carduccf, M.

AU - Mussi, A.

AU - D'Auria, L.

AU - Ameglio, F.

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N2 - A still debated question in the field of the cytokine network in psoriasis is represented by contrasting data reported on the local amount of IL-1 in this dermatosis. In fact previous studies have suggested that there were decreased IL-1 alpha amounts at the lesional level but increased non-functional IL-1 beta concentrations as compared to the non-lesional and normal epidermis. However, recent data suggest that IL-1 alpha and to a lesser extent, IL-1 beta amounts, are both increased and biologically active in the epidermal cell suspension of lesional psoriatic skin as compared to those of normal skin. The data reported in the present paper show that IL-1 alpha levels are decreased in psoriatic lesional extracts of whole skin (mean 2.9 ± 2 pg/mg) as compared to non-lesional (mean 6.7 ± 6.2 mg/mg, p = 0.02) or normal skin (mean 13.8 ± 9.4 pg/mg; p = 0.0002). IL-1 alpha concentrations were also significantly lower in the non-lesional skin than in normal skin (p = 0.02). In contrast, the IL-1 beta levels (mean 1.2 ± 0.74 pg/mg) were higher in the lesional samples than in the non-lesional ones (mean 0.5 ± 0.4 pg/mg, p = 0.004) or in normal skin (mean 0.4 ± 0.2 pg/mg, p = 0.004). No differences in IL-1 beta levels were observed between non-lesional and normal skin (p = 0.3). In addition both IL-1 alpha and IL-1 beta are directly correlated with the disease severity and each other. Our data, extending the IL-1 determination to the whole skin, seem to confirm the previously reported findings at the epidermis level and provide new light on possible interpretation of literature discrepancies.

AB - A still debated question in the field of the cytokine network in psoriasis is represented by contrasting data reported on the local amount of IL-1 in this dermatosis. In fact previous studies have suggested that there were decreased IL-1 alpha amounts at the lesional level but increased non-functional IL-1 beta concentrations as compared to the non-lesional and normal epidermis. However, recent data suggest that IL-1 alpha and to a lesser extent, IL-1 beta amounts, are both increased and biologically active in the epidermal cell suspension of lesional psoriatic skin as compared to those of normal skin. The data reported in the present paper show that IL-1 alpha levels are decreased in psoriatic lesional extracts of whole skin (mean 2.9 ± 2 pg/mg) as compared to non-lesional (mean 6.7 ± 6.2 mg/mg, p = 0.02) or normal skin (mean 13.8 ± 9.4 pg/mg; p = 0.0002). IL-1 alpha concentrations were also significantly lower in the non-lesional skin than in normal skin (p = 0.02). In contrast, the IL-1 beta levels (mean 1.2 ± 0.74 pg/mg) were higher in the lesional samples than in the non-lesional ones (mean 0.5 ± 0.4 pg/mg, p = 0.004) or in normal skin (mean 0.4 ± 0.2 pg/mg, p = 0.004). No differences in IL-1 beta levels were observed between non-lesional and normal skin (p = 0.3). In addition both IL-1 alpha and IL-1 beta are directly correlated with the disease severity and each other. Our data, extending the IL-1 determination to the whole skin, seem to confirm the previously reported findings at the epidermis level and provide new light on possible interpretation of literature discrepancies.

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