IL-1 genes in myasthenia gravis: IL-1A-889 polymorphism associated with sex and age of disease onset

Francesca L. Sciacca, Cinzia Ferri, Fabrizio Veglia, Francesca Andreetta, Renato Mantegazza, Ferdinando Cornelio, Diego Franciotta, Giovanni Piccolo, Vittorio Cosi, Anna P. Batocchi, Amelia Evoli, L. M E Grimaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalJournal of Neuroimmunology
Volume122
Issue number1-2
DOIs
Publication statusPublished - 2002

Keywords

  • Age of onset
  • Interleukin-1
  • Myasthenia gravis
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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