IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus

J. Geginat, M. Vasco, M. Gerosa, S. W. Tas, M. Pagani, F. Grassi, R. A. Flavell, Pl Meroni, S. Abrignani

Research output: Contribution to journalReview articlepeer-review

Abstract

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease characterised by the production of pathogenic autoantibodies against nuclear self-antigens. The anti-inflammatory and tolerogenic cytokine Interleukin-10 appears to play a paradoxical pathogenic role in SLE and is therefore currently therapeutically targeted in clinical trials. It is generally assumed that the pathogenic effect of IL-10 in SLE is due to its growth and differentiation factor activity on autoreactive B-cells, but effects on other cells might also play a role. To date, a unique cellular source of pathogenic IL-10 in SLE has not been identified. In this review, we focus on the contribution of different CD4+T-cell subsets to IL-10 and autoantibody production in SLE. In particular, we discuss that IL-10 produced by different subsets of adaptive regulatory T-cells, follicular helper T-cells and extra-follicular B-helper T-cells is likely to have different effects on autoreactive B-cell responses. A better understanding of the role of IL-10 in B-cell responses and lupus would allow to identify the most promising therapies for individual SLE patients in the future.

Original languageEnglish
Article number101330
JournalSeminars in Immunology
Volume44
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Autoantibodies
  • CD4T-cells
  • IL-10
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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