IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: Preliminary findings

M. Gelati, E. Lamperti, A. Dufour, E. Corsini, E. Venegoni, C. Milanese, A. Nespolo, A. Salmaggi

Research output: Contribution to journalArticlepeer-review

Abstract

IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA- stimulated PBMNCs from MS patients produced large amounts of the cytokine.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • IL-10
  • SLE
  • SM
  • Steroids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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