Abstract
IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA- stimulated PBMNCs from MS patients produced large amounts of the cytokine.
Original language | English |
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Pages (from-to) | 191-194 |
Number of pages | 4 |
Journal | Italian Journal of Neurological Sciences |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1997 |
Keywords
- IL-10
- SLE
- SM
- Steroids
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology