IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: Preliminary findings

M. Gelati; E. Lamperti; A. Dufour; E. Corsini; E. Venegoni; C. Milanese; A. Nespolo; A. Salmaggi

doi:10.1007/BF02080463

IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: Preliminary findings

M. Gelati, E. Lamperti, A. Dufour, E. Corsini, E. Venegoni, C. Milanese, A. Nespolo, A. Salmaggi

Research output: Contribution to journal › Article › peer-review

Abstract

IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA- stimulated PBMNCs from MS patients produced large amounts of the cytokine.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Italian Journal of Neurological Sciences
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/BF02080463
Publication status	Published - 1997

Keywords

IL-10
SLE
SM
Steroids

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology
Psychiatry and Mental health
Dermatology

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abstract = "IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA- stimulated PBMNCs from MS patients produced large amounts of the cytokine.",

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AU - Gelati, M.

AU - Lamperti, E.

AU - Dufour, A.

AU - Corsini, E.

AU - Venegoni, E.

AU - Milanese, C.

AU - Nespolo, A.

AU - Salmaggi, A.

PY - 1997

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AB - IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA- stimulated PBMNCs from MS patients produced large amounts of the cytokine.

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IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: Preliminary findings

Abstract

Keywords

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