IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients.

Rossana Tallerico, Costanza M. Cristiani, Elina Staaf, Cinzia Garofalo, Rosa Sottile, Mariaelena Capone, Yago Pico de Coana, Gabriele Madonna, Eleonora Palella, Maria Wolodarski, Valentina Carannante, Domenico Mallardo, Ester Simeone, Antonio M. Grimaldi, Sofia Johansson, Paolo Frumento, Elio Gulletta, Andrea Anichini, Francesco Colucci, Gennaro CilibertoRolf Kiessling, Klas Karre, Paolo A. Ascierto, Ennio Carbone

Research output: Contribution to journalArticle

Abstract

Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and clinical outcome of anti-CTLA-4 treatment. We thus characterized the NK and T cell phenotype, as well as serum levels of several cytokines in 67 melanoma patients recruited in Italy and Sweden, using samples drawn prior to and during treatment. Survival correlated with low expression of the inhibitory receptor
Original languageUndefined/Unknown
Pages (from-to)e1261242
JournalOncoImmunology
Volume6
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Anti-CTLA-4, IL-15, melanoma, NK cells, PD-1, TIM-3

Cite this

Tallerico, R., Cristiani, C. M., Staaf, E., Garofalo, C., Sottile, R., Capone, M., ... Carbone, E. (2017). IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients. OncoImmunology, 6(2), e1261242. https://doi.org/10.1080/2162402X.2016.1261242