IL-17-and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity

Marianna Esposito, Francesca Ruffini, Alessandra Bergami, Livia Garzetti, Giovanna Borsellino, Luca Battistini, Gianvito Martino, Roberto Furlan

Research output: Contribution to journalArticlepeer-review

Abstract

CD4+Foxp3+ regulatory T cells (Tregs) have been considered crucial in controlling immune system homeostasis, and their derangement is often associated to autoimmunity. Tregs identification is, however, difficult because most markers, including CD25 and Foxp3, are shared by recently activated T cells. We show in this paper that CD4+Foxp3+ T cells are generated in peripheral lymphoid organs on immunization and readily accumulate in the target organ of an autoimmune reaction, together with classical inflammatory cells, constituting up to 50% of infiltrating CD4+ T cells. Most CD4+Foxp3+ T cells are, however, CD252 and express proinflammatory cytokines such as IL-17 and IFN-g, questioning their suppressive nature. Moreover, in vitro CD4+ T lymphocytes from naive and autoimmune mice, stimulated to differentiate into Th1, Th2, Th17, and induced Tregs, display early mixed expression of lineage-specific markers. These results clearly point to an unprecedented plasticity of naive CD4+ T cells, that integrating inflammatory signals may change their fate from the initial lineage commitment to a different functional phenotype.

Original languageEnglish
Pages (from-to)7467-7473
Number of pages7
JournalJournal of Immunology
Volume185
Issue number12
DOIs
Publication statusPublished - Dec 15 2010

ASJC Scopus subject areas

  • Immunology

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