IL-17 and IL-22: siblings, not twins

Stefanie Eyerich, Kilian Eyerich, Andrea Cavani, Carsten Schmidt-Weber

Research output: Contribution to journalArticle

Abstract

T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalTrends in Immunology
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

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    Eyerich, S., Eyerich, K., Cavani, A., & Schmidt-Weber, C. (2010). IL-17 and IL-22: siblings, not twins. Trends in Immunology, 31(9), 354-361. https://doi.org/10.1016/j.it.2010.06.004