IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Ludovica Segat; Daiana Bevilacqua; Michele Boniotto; Luiz C. Arraes; Paulo R. De Souza; Josè L. De Lima Filho; Sergio Crovella

doi:10.1007/s00251-006-0104-7

IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Ludovica Segat, Daiana Bevilacqua, Michele Boniotto, Luiz C. Arraes, Paulo R. De Souza, Josè L. De Lima Filho, Sergio Crovella

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.

Original language	English
Pages (from-to)	471-473
Number of pages	3
Journal	Immunogenetics
Volume	58
Issue number	5-6
DOIs	https://doi.org/10.1007/s00251-006-0104-7
Publication status	Published - Jun 2006

Keywords

Brazilian children
HIV-1 infection
IL-18
Promoter polymorphism
Single-tube allele-specific PCR

ASJC Scopus subject areas

Immunology
Genetics

Access to Document

10.1007/s00251-006-0104-7

Cite this

@article{c51a7c54f99b4ec883ad1bcfefee4d69,

title = "IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population",

abstract = "In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.",

keywords = "Brazilian children, HIV-1 infection, IL-18, Promoter polymorphism, Single-tube allele-specific PCR",

author = "Ludovica Segat and Daiana Bevilacqua and Michele Boniotto and Arraes, {Luiz C.} and {De Souza}, {Paulo R.} and {De Lima Filho}, {Jos{\`e} L.} and Sergio Crovella",

year = "2006",

month = jun,

doi = "10.1007/s00251-006-0104-7",

language = "English",

volume = "58",

pages = "471--473",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer Verlag",

number = "5-6",

}

TY - JOUR

T1 - IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

AU - Segat, Ludovica

AU - Bevilacqua, Daiana

AU - Boniotto, Michele

AU - Arraes, Luiz C.

AU - De Souza, Paulo R.

AU - De Lima Filho, Josè L.

AU - Crovella, Sergio

PY - 2006/6

Y1 - 2006/6

N2 - In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.

AB - In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.

KW - Brazilian children

KW - HIV-1 infection

KW - IL-18

KW - Promoter polymorphism

KW - Single-tube allele-specific PCR

UR - http://www.scopus.com/inward/record.url?scp=33744832204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744832204&partnerID=8YFLogxK

U2 - 10.1007/s00251-006-0104-7

DO - 10.1007/s00251-006-0104-7

M3 - Article

C2 - 16738942

AN - SCOPUS:33744832204

VL - 58

SP - 471

EP - 473

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 5-6

ER -

IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this