IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Ludovica Segat, Daiana Bevilacqua, Michele Boniotto, Luiz C. Arraes, Paulo R. De Souza, Josè L. De Lima Filho, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.

Original languageEnglish
Pages (from-to)471-473
Number of pages3
JournalImmunogenetics
Volume58
Issue number5-6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Brazilian children
  • HIV-1 infection
  • IL-18
  • Promoter polymorphism
  • Single-tube allele-specific PCR

ASJC Scopus subject areas

  • Immunology
  • Genetics

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