IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan Jonjić, Angela Santoni, Cecilia Garlanda, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation. Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses. NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis. Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalNature
Volume551
Issue number7678
DOIs
Publication statusPublished - Nov 2 2017

ASJC Scopus subject areas

  • General

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    Molgora, M., Bonavita, E., Ponzetta, A., Riva, F., Barbagallo, M., Jaillon, S., Popović, B., Bernardini, G., Magrini, E., Gianni, F., Zelenay, S., Jonjić, S., Santoni, A., Garlanda, C., & Mantovani, A. (2017). IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature, 551(7678), 110-114. https://doi.org/10.1038/nature24293