TY - JOUR
T1 - IL-2, TNF-α, and leptin
T2 - Local versus systemic concentrations in NSCLC patients
AU - Carpagnano, Giovanna E.
AU - Spanevello, Antonio
AU - Curci, Claudia
AU - Salerno, Francesco
AU - Palladino, Grazia P.
AU - Resta, Onofrio
AU - Di Gioia, Giuseppe
AU - Carpagnano, Francesco
AU - Foschino Barbaro, Maria P.
PY - 2007
Y1 - 2007
N2 - One recent line of cancer research shows increasing interest for biological factor such as IL-2, TNF-α, and leptin, which have been found to participate in the development and progression of non-small cell lung cancer (NSCLC). The aim of this study was to measure IL-2, TNF-α, and leptin concentrations in the airways and in the systemic circle of patients with NSCLC, investigating the role of these factors in the lung tumors. We enrolled 32 patients (17 men, 71 ± 7 years) with a histological diagnosis of NSCLC and 20 healthy ex-smoker controls, negative for computed tomography of the chest (14 men, 69 ± 8 years). IL-2, TNF-α, and leptin levels were measured in the serum, the urine, the bronchoalveolar lavage, the induced sputum, and exhaled breath condensate (EBC) of patients enrolled by means of a specific enzyme immunoassay kit. Higher concentrations of IL-2, TNF-α and leptin were found in NSCLC patients than in controls (p <0.0001). A statistically significant increase of IL-2, TNF-α, and leptin concentrations was observed in patients from stage I to stage III of NSCLC. These findings suggest that IL-2, TNF-α, and the leptin play an important role in the cancerogenesis of NSCLC. Their measure in the EBC could be proposed as noninvasive markers for an early detection of NSCLC and in the follow-up of this tumor.
AB - One recent line of cancer research shows increasing interest for biological factor such as IL-2, TNF-α, and leptin, which have been found to participate in the development and progression of non-small cell lung cancer (NSCLC). The aim of this study was to measure IL-2, TNF-α, and leptin concentrations in the airways and in the systemic circle of patients with NSCLC, investigating the role of these factors in the lung tumors. We enrolled 32 patients (17 men, 71 ± 7 years) with a histological diagnosis of NSCLC and 20 healthy ex-smoker controls, negative for computed tomography of the chest (14 men, 69 ± 8 years). IL-2, TNF-α, and leptin levels were measured in the serum, the urine, the bronchoalveolar lavage, the induced sputum, and exhaled breath condensate (EBC) of patients enrolled by means of a specific enzyme immunoassay kit. Higher concentrations of IL-2, TNF-α and leptin were found in NSCLC patients than in controls (p <0.0001). A statistically significant increase of IL-2, TNF-α, and leptin concentrations was observed in patients from stage I to stage III of NSCLC. These findings suggest that IL-2, TNF-α, and the leptin play an important role in the cancerogenesis of NSCLC. Their measure in the EBC could be proposed as noninvasive markers for an early detection of NSCLC and in the follow-up of this tumor.
KW - Exhaled breath condensate
KW - IL-2
KW - Leptin
KW - Non-small cell lung cancer (NSCLC)
KW - Systemic circle
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=34548687010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548687010&partnerID=8YFLogxK
M3 - Article
C2 - 17913045
AN - SCOPUS:34548687010
VL - 16
SP - 375
EP - 381
JO - Oncology Research
JF - Oncology Research
SN - 0965-0407
IS - 8
ER -