IL-21: A new player in the control of isotype switch in Peyer's patches

Vito Pistoia, Claudia Cocco

Research output: Contribution to journalArticlepeer-review

Abstract

Peyer's patches (PP) are lymphoid follicles of the small intestine containing predominantly IgA+ B cells. In this JLB issue, IL-21 is reported to dampen TGF-β1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA+ B cells predominate in PP.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalJournal of Leukocyte Biology
Volume85
Issue number5
DOIs
Publication statusPublished - May 1 2009

Keywords

  • Class-switch recombination
  • Cytokines
  • Gut lymphoid tissue
  • IgA

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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