IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

Mara Biasin, Adriano Boasso, Luca Piacentini, Daria Trabattoni, Giuliana Magri, Ranjana Deshmuks, Alaka Deshpande, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.

Original languageEnglish
Pages (from-to)1563-1565
Number of pages3
JournalAIDS (London, England)
Volume17
Issue number10
Publication statusPublished - Jul 4 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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