IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

Mara Biasin; Adriano Boasso; Luca Piacentini; Daria Trabattoni; Giuliana Magri; Ranjana Deshmuks; Alaka Deshpande; Mario Clerici

IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

Mara Biasin, Adriano Boasso, Luca Piacentini, Daria Trabattoni, Giuliana Magri, Ranjana Deshmuks, Alaka Deshpande, Mario Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.

Original language	English
Pages (from-to)	1563-1565
Number of pages	3
Journal	AIDS (London, England)
Volume	17
Issue number	10
Publication status	Published - Jul 4 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai. / Biasin, Mara; Boasso, Adriano; Piacentini, Luca; Trabattoni, Daria; Magri, Giuliana; Deshmuks, Ranjana; Deshpande, Alaka; Clerici, Mario.

In: AIDS (London, England), Vol. 17, No. 10, 04.07.2003, p. 1563-1565.

Research output: Contribution to journal › Article › peer-review

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AU - Biasin, Mara

AU - Boasso, Adriano

AU - Piacentini, Luca

AU - Trabattoni, Daria

AU - Magri, Giuliana

AU - Deshmuks, Ranjana

AU - Deshpande, Alaka

AU - Clerici, Mario

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N2 - We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.

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IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

Abstract

ASJC Scopus subject areas

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