Abstract
We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
Original language | English |
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Pages (from-to) | 1563-1565 |
Number of pages | 3 |
Journal | AIDS (London, England) |
Volume | 17 |
Issue number | 10 |
Publication status | Published - Jul 4 2003 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology