IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients

Giulia Marchetti, Luca Meroni, Chiara Molteni, Greta Taskaris, Lidia Gazzola, Massimo Galli, Mario Clerici, Mauro Moroni, Fabio Franzetti, Andrea Gori

Research output: Contribution to journalArticle

Abstract

Interleukin-2 (IL-2) and IL-7 are the most intriguing molecules in immune-based HIV infection treatment. An in vitro IL-2/IL-7 cross-talk due to IL-2-driven IL-7 receptor-α-chain (IL-7Rα) down-modulation, potentially blocking IL-7 signalling has been described. We investigated the in vivo IL-2 effect on IL-7/IL-7R system, measuring free IL-7, and IL-7Rα CD4 and CD8 in 12 HIV-positive patients enrolled in a randomized IL-2 trial. Compared to HAART alone, IL-2 induced a parallel expansion in total and naive CD4, TRECs and IL-7 plasma levels, with no IL-7Rα CD4 and IL-7Rα CD8 changes (P>0.05), suggesting that in vivo IL-2 boosts IL-7 production without down-modulating IL-7Rα, preserving IL-7-mediated T-lymphocyte homeostatic regulation. Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalAntiviral Therapy
Volume9
Issue number3
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Pharmacology

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    Marchetti, G., Meroni, L., Molteni, C., Taskaris, G., Gazzola, L., Galli, M., Clerici, M., Moroni, M., Franzetti, F., & Gori, A. (2004). IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients. Antiviral Therapy, 9(3), 447-452.