IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration

Stefano Lazzeri; Paola Orlandi; Paolo Piaggi; Maria S ole Sartini; Giamberto Casini; Gianluca Guidi; Michele Figus; Anna Fioravanti; Teresa Di Desidero; Guido Ripandelli; Mariacristina Parravano; Monica Varano; Marco Nardi; Guido Bocci

doi:10.2217/pgs.15.153

IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration

Stefano Lazzeri, Paola Orlandi, Paolo Piaggi, Maria S ole Sartini, Giamberto Casini, Gianluca Guidi, Michele Figus, Anna Fioravanti, Teresa Di Desidero, Guido Ripandelli, Mariacristina Parravano, Monica Varano, Marco Nardi, Guido Bocci

Fondazione G.B. Bietti

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.

MATERIALS & METHODS: Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.

RESULTS: Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).

CONCLUSION: IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Pharmacogenomics
Volume	17
Issue number	1
DOIs	https://doi.org/10.2217/pgs.15.153
Publication status	Published - 2016

Keywords

age-related macular degeneration
IL-8
pharmacogenetics
ranibizumab
SNPs
VEGF-2

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology

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Lazzeri, S., Orlandi, P., Piaggi, P., Sartini, M. S. O., Casini, G., Guidi, G., Figus, M., Fioravanti, A., Di Desidero, T., Ripandelli, G., Parravano, M., Varano, M., Nardi, M., & Bocci, G. (2016). IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. Pharmacogenomics, 17(1), 35-39. https://doi.org/10.2217/pgs.15.153

IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. / Lazzeri, Stefano; Orlandi, Paola; Piaggi, Paolo; Sartini, Maria S ole; Casini, Giamberto; Guidi, Gianluca; Figus, Michele; Fioravanti, Anna; Di Desidero, Teresa; Ripandelli, Guido ; Parravano, Mariacristina ; Varano, Monica; Nardi, Marco; Bocci, Guido.

In: Pharmacogenomics, Vol. 17, No. 1, 2016, p. 35-39.

Research output: Contribution to journal › Article › peer-review

Lazzeri, S, Orlandi, P, Piaggi, P, Sartini, MSO, Casini, G, Guidi, G, Figus, M, Fioravanti, A, Di Desidero, T, Ripandelli, G , Parravano, M , Varano, M, Nardi, M & Bocci, G 2016, 'IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration', Pharmacogenomics, vol. 17, no. 1, pp. 35-39. https://doi.org/10.2217/pgs.15.153

Lazzeri, Stefano ; Orlandi, Paola ; Piaggi, Paolo ; Sartini, Maria S ole ; Casini, Giamberto ; Guidi, Gianluca ; Figus, Michele ; Fioravanti, Anna ; Di Desidero, Teresa ; Ripandelli, Guido ; Parravano, Mariacristina ; Varano, Monica ; Nardi, Marco ; Bocci, Guido. / IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. In: Pharmacogenomics. 2016 ; Vol. 17, No. 1. pp. 35-39.

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abstract = "AIM: To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.MATERIALS & METHODS: Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.RESULTS: Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).CONCLUSION: IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.",

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AU - Sartini, Maria S ole

AU - Casini, Giamberto

AU - Guidi, Gianluca

AU - Figus, Michele

AU - Fioravanti, Anna

AU - Di Desidero, Teresa

AU - Ripandelli, Guido

AU - Parravano, Mariacristina

AU - Varano, Monica

AU - Nardi, Marco

AU - Bocci, Guido

PY - 2016

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N2 - AIM: To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.MATERIALS & METHODS: Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.RESULTS: Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).CONCLUSION: IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.

AB - AIM: To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.MATERIALS & METHODS: Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.RESULTS: Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).CONCLUSION: IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.

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