Abstract
AIM: To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.
MATERIALS & METHODS: Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.
RESULTS: Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).
CONCLUSION: IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.
Original language | English |
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Pages (from-to) | 35-39 |
Number of pages | 5 |
Journal | Pharmacogenomics |
Volume | 17 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- age-related macular degeneration
- IL-8
- pharmacogenetics
- ranibizumab
- SNPs
- VEGF-2
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmacology