IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma

Ignazia Prigione, Angela Elvira Covone, Francesca Giacopelli, Paola Bocca, Marco Risso, Gino Tripodi, Angela Pistorio, Gabriella Sozzi, Irma Airoldi, Roberto Ravazzolo, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

In a previous study, lack of IL-12 signaling in il12rb2 knock-out mice was found to predispose to lung adenocarcinoma (LAC). We asked whether specific polymorphisms of the human IL12RB2 gene may confer susceptibility to LAC. We studied IL12RB2 single nucleotide polymorphisms (SNPs) spanning from the promoter to the first untranslated exon of the gene. Genotypes of 49 individuals with LAC were compared with those of 93 healthy subjects. Two allele variants were found to be associated with increased susceptibility to LAC. One haplotype (hap), hap18, was more frequent in patients (18%) versus controls (6%) and significantly associated with increased probability of disease occurrence. Furthermore, IL-12 driven STAT4 phosphorylation in T cell blasts from healthy individuals was found to correlate with both single allele variants and haplotypes. In conclusion, genetically determined low signaling activity of IL-12R predisposes to the development of LAC.

Original languageEnglish
Pages (from-to)291-299
Number of pages9
JournalImmunobiology
Volume221
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Genotype–phenotype association
  • Lung adenocarcinoma susceptibility
  • STAT4 Phosphorylation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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