IL28B CC-genotype association with HLA-DQB1*0301 allele increases the prediction of spontaneous HCV RNA clearance in thalassaemic HCV-infected patients

Alessandra Mangia, Rosanna Santoro, Roberto Sarli, Leonardo Mottola, Valeria Piazzolla, Daniela Petruzzellis, Donato Bacca, Rocco Clemente, Massimiliano Copetti, Lazzaro Di Mauro, Giuseppe Lotti, Michele Sacco, Ippazio Stefano

Research output: Contribution to journalArticle

Abstract

Background: A single nucleotide polymorphism (SNP), upstream of the IL28B gene has been recently associated with natural clearance of HCV. In a well-characterized cohort of patients with thalassaemia major exposed to the risk of acquiring HCV infection by blood transfusions, we aimed to replicate this finding and to evaluate whether combining the IL28B genotype and HLA class II alleles allow viral clearance to be accurately predicted. Methods: Of 168 patients, 130 with complete clinical history were included in the analysis. According with their HCV antibodies status 13 were defined HCV resistant, and 117 infected. Infected patients were subdivided, giving 49 with self-limiting and 68 with ongoing infection. Results: IL28B CC-genotype was observed in 32 patients with self-limiting and in 23 with ongoing infection (64% versus 34%; P=0.004). HLA DQB1*0301 allele was associated with viral clearance in 36 cases (73%; P

Original languageEnglish
Pages (from-to)1309-1316
Number of pages8
JournalAntiviral Therapy
Volume16
Issue number8
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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