IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

S. Malhotra, C. Morcillo-Suárez, D. Brassat, R. Goertsches, J. Lechner-Scott, E. Urcelay, O. Fernández, J. Drulovic, A. García-Merino, F. Martinelli Boneschi, A. Chan, K. Vandenbroeck, A. Navarro, M. F. Bustamante, J. Río, D. A. Akkad, G. Giacalone, A. J. Sánchez, L. Leyva, R. Alvarez-LafuenteU. K. Zettl, J. Oksenberg, X. Montalban, M. Comabella

Research output: Contribution to journalArticle

Abstract

Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of Neuroimmunology
Volume239
Issue number1-2
DOIs
Publication statusPublished - Oct 28 2011

Keywords

  • Interferon-beta
  • Multiple sclerosis
  • Polymorphisms
  • Response

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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    Malhotra, S., Morcillo-Suárez, C., Brassat, D., Goertsches, R., Lechner-Scott, J., Urcelay, E., Fernández, O., Drulovic, J., García-Merino, A., Martinelli Boneschi, F., Chan, A., Vandenbroeck, K., Navarro, A., Bustamante, M. F., Río, J., Akkad, D. A., Giacalone, G., Sánchez, A. J., Leyva, L., ... Comabella, M. (2011). IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis. Journal of Neuroimmunology, 239(1-2), 101-104. https://doi.org/10.1016/j.jneuroim.2011.08.004