IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C

G. Fattovich; L. Covolo; S. Bibert; G. Askarieh; M. Lagging; S. Clément; G. Malerba; M. Pasino; M. Guido; M. Puoti; G. B. Gaeta; T. Santantonio; G. Raimondo; R. Bruno; P. Y. Bochud; F. Donato; F. Negro

doi:10.1111/j.1365-2036.2011.04635.x

IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C

G. Fattovich, L. Covolo, S. Bibert, G. Askarieh, M. Lagging, S. Clément, G. Malerba, M. Pasino, M. Guido, M. Puoti, G. B. Gaeta, T. Santantonio, G. Raimondo, R. Bruno, P. Y. Bochud, F. Donato, F. Negro

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Aliment Pharmacol Ther 2011; 33: 1162-1172 Summary Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue. Aim To determine the independent contribution of factors including IL28B polymorphisms, IFN-gamma inducible protein-10 (IP-10) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) score in predicting response to therapy in chronic hepatitis C (CHC). Methods Multivariate analysis of factors predicting rapid (RVR) and sustained (SVR) virological response in 280 consecutive, treatment-naive CHC patients treated with peginterferon alpha and ribavirin in a prospective multicentre study. Results Independent predictors of RVR were HCV RNA

Original language	English
Pages (from-to)	1162-1172
Number of pages	11
Journal	Alimentary Pharmacology and Therapeutics
Volume	33
Issue number	10
DOIs	https://doi.org/10.1111/j.1365-2036.2011.04635.x
Publication status	Published - May 2011

ASJC Scopus subject areas

Pharmacology (medical)

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Fattovich, G., Covolo, L., Bibert, S., Askarieh, G., Lagging, M., Clément, S., Malerba, G., Pasino, M., Guido, M., Puoti, M., Gaeta, G. B., Santantonio, T., Raimondo, G., Bruno, R., Bochud, P. Y., Donato, F., & Negro, F. (2011). IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C. Alimentary Pharmacology and Therapeutics, 33(10), 1162-1172. https://doi.org/10.1111/j.1365-2036.2011.04635.x

IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C. / Fattovich, G.; Covolo, L.; Bibert, S.; Askarieh, G.; Lagging, M.; Clément, S.; Malerba, G.; Pasino, M.; Guido, M.; Puoti, M.; Gaeta, G. B.; Santantonio, T.; Raimondo, G.; Bruno, R.; Bochud, P. Y.; Donato, F.; Negro, F.

In: Alimentary Pharmacology and Therapeutics, Vol. 33, No. 10, 05.2011, p. 1162-1172.

Research output: Contribution to journal › Article › peer-review

Fattovich, G, Covolo, L, Bibert, S, Askarieh, G, Lagging, M, Clément, S, Malerba, G, Pasino, M, Guido, M, Puoti, M, Gaeta, GB, Santantonio, T, Raimondo, G, Bruno, R, Bochud, PY, Donato, F & Negro, F 2011, 'IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C', Alimentary Pharmacology and Therapeutics, vol. 33, no. 10, pp. 1162-1172. https://doi.org/10.1111/j.1365-2036.2011.04635.x

Fattovich, G. ; Covolo, L. ; Bibert, S. ; Askarieh, G. ; Lagging, M. ; Clément, S. ; Malerba, G. ; Pasino, M. ; Guido, M. ; Puoti, M. ; Gaeta, G. B. ; Santantonio, T. ; Raimondo, G. ; Bruno, R. ; Bochud, P. Y. ; Donato, F. ; Negro, F. / IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C. In: Alimentary Pharmacology and Therapeutics. 2011 ; Vol. 33, No. 10. pp. 1162-1172.

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abstract = "Aliment Pharmacol Ther 2011; 33: 1162-1172 Summary Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue. Aim To determine the independent contribution of factors including IL28B polymorphisms, IFN-gamma inducible protein-10 (IP-10) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) score in predicting response to therapy in chronic hepatitis C (CHC). Methods Multivariate analysis of factors predicting rapid (RVR) and sustained (SVR) virological response in 280 consecutive, treatment-naive CHC patients treated with peginterferon alpha and ribavirin in a prospective multicentre study. Results Independent predictors of RVR were HCV RNA ",

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AU - Fattovich, G.

AU - Covolo, L.

AU - Bibert, S.

AU - Askarieh, G.

AU - Lagging, M.

AU - Clément, S.

AU - Malerba, G.

AU - Pasino, M.

AU - Guido, M.

AU - Puoti, M.

AU - Gaeta, G. B.

AU - Santantonio, T.

AU - Raimondo, G.

AU - Bruno, R.

AU - Bochud, P. Y.

AU - Donato, F.

AU - Negro, F.

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AB - Aliment Pharmacol Ther 2011; 33: 1162-1172 Summary Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue. Aim To determine the independent contribution of factors including IL28B polymorphisms, IFN-gamma inducible protein-10 (IP-10) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) score in predicting response to therapy in chronic hepatitis C (CHC). Methods Multivariate analysis of factors predicting rapid (RVR) and sustained (SVR) virological response in 280 consecutive, treatment-naive CHC patients treated with peginterferon alpha and ribavirin in a prospective multicentre study. Results Independent predictors of RVR were HCV RNA

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