IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C

G. Fattovich, L. Covolo, S. Bibert, G. Askarieh, M. Lagging, S. Clément, G. Malerba, M. Pasino, M. Guido, M. Puoti, G. B. Gaeta, T. Santantonio, G. Raimondo, R. Bruno, P. Y. Bochud, F. Donato, F. Negro

Research output: Contribution to journalArticlepeer-review

Abstract

Aliment Pharmacol Ther 2011; 33: 1162-1172 Summary Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue. Aim To determine the independent contribution of factors including IL28B polymorphisms, IFN-gamma inducible protein-10 (IP-10) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) score in predicting response to therapy in chronic hepatitis C (CHC). Methods Multivariate analysis of factors predicting rapid (RVR) and sustained (SVR) virological response in 280 consecutive, treatment-naive CHC patients treated with peginterferon alpha and ribavirin in a prospective multicentre study. Results Independent predictors of RVR were HCV RNA

Original languageEnglish
Pages (from-to)1162-1172
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume33
Issue number10
DOIs
Publication statusPublished - May 2011

ASJC Scopus subject areas

  • Pharmacology (medical)

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