IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation

R Dvir, V Paloschi, F Canducci, G Dell'Antonio, Sara Racca, R Caldara, G Pantaleo, M Clementi, A Secchi

Research output: Contribution to journalArticle

Abstract

BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV-replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN-): 22 patients with active BKV-replication but without evidence of BKVAN; Group 3 (BKV-/BKVAN-): 17 patients without evidence of BKV-replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV-reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly. © 2017 The Author(s).
Original languageEnglish
Article number6746
JournalScientific Reports
Volume7
Issue number34
DOIs
Publication statusPublished - 2017

Fingerprint

BK Virus
Kidney Transplantation
Genotype
Interferons
Virus Replication
Kidney
Antiviral Agents
Single Nucleotide Polymorphism
Allografts
Epithelium
Epithelial Cells
Biopsy
Control Groups

Cite this

IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation. / Dvir, R; Paloschi, V; Canducci, F; Dell'Antonio, G; Racca, Sara; Caldara, R; Pantaleo, G; Clementi, M; Secchi, A.

In: Scientific Reports, Vol. 7, No. 34, 6746, 2017.

Research output: Contribution to journalArticle

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abstract = "BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV-replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN-): 22 patients with active BKV-replication but without evidence of BKVAN; Group 3 (BKV-/BKVAN-): 17 patients without evidence of BKV-replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV-reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly. {\circledC} 2017 The Author(s).",
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T1 - IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation

AU - Dvir, R

AU - Paloschi, V

AU - Canducci, F

AU - Dell'Antonio, G

AU - Racca, Sara

AU - Caldara, R

AU - Pantaleo, G

AU - Clementi, M

AU - Secchi, A

PY - 2017

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N2 - BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV-replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN-): 22 patients with active BKV-replication but without evidence of BKVAN; Group 3 (BKV-/BKVAN-): 17 patients without evidence of BKV-replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV-reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly. © 2017 The Author(s).

AB - BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV-replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN-): 22 patients with active BKV-replication but without evidence of BKVAN; Group 3 (BKV-/BKVAN-): 17 patients without evidence of BKV-replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV-reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly. © 2017 The Author(s).

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