Image analysis software for following progression of peripheral neuropathy

T. Epplin-Zapf, C. Miller, S. Larkin, E. Hermesmeyer, J. Macy, M. Pellegrini, S. Luccarelli, G. Staurenghi, T. Holmes

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A relationship has been reported by several research groups [1-4] between the density and shapes of nerve fibers in the cornea and the existence and severity of peripheral neuropathy. Peripheral neuropathy is a complication of several prevalent diseases or conditions, which include diabetes, HIV, prolonged alcohol overconsumption and aging. A common clinical technique for confirming the condition is intramuscular electromyography (EMG), which is invasive, so a noninvasive technique like the one proposed here carries important potential advantages for the physician and patient. A software program that automatically detects the nerve fibers, counts them and measures their shapes is being developed and tested. Tests were carried out with a database of subjects with levels of severity of diabetic neuropathy as determined by EMG testing. Results from this testing, that include a linear regression analysis are shown.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 2009
EventAdvanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009


OtherAdvanced Biomedical and Clinical Diagnostic Systems VII
Country/TerritoryUnited States
CitySan Jose, CA

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


Dive into the research topics of 'Image analysis software for following progression of peripheral neuropathy'. Together they form a unique fingerprint.

Cite this