Image processing method for 3D volume rendering from one 2D projection: Application to Cancer spheroids

Filippo Piccinini, Anna Tesei, Wainer Zoli, Alessandro Bevilacqua

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Shape and volume are two of the most important features of a tumour. In particular, the treatment choices of a tumour are often driven by its volume. Accordingly, the correct estimation of the volume is fundamental to assess the effectiveness of therapy. Very few methods have been proposed in the literature to accurately estimate the tumour's volume arising from one 2D projection and even less provide a 3D reconstruction of the tumour shape, that is important for the clinical evaluation. In this work, we address the morphology of tumour spheroids typically employed for testing drugs, chemotherapy and radiotherapy treatments in pre-clinical studies. In particular, we propose a new 3D volume rendering method based on the assumption of spherical symmetry of the object around the principal axis. By using real-world, home-made 3D models, mimicking the spheroid morphology, we proved the effectiveness of our method for both 3D reconstruction and volume assessment.

Original languageEnglish
Title of host publication2014 4th International Conference on Image Processing Theory, Tools and Applications, IPTA 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479964611
DOIs
Publication statusPublished - Jan 6 2015
Event4th International Conference on Image Processing Theory, Tools and Applications, IPTA 2014 - Paris, France
Duration: Oct 14 2014Oct 17 2014

Other

Other4th International Conference on Image Processing Theory, Tools and Applications, IPTA 2014
CountryFrance
CityParis
Period10/14/1410/17/14

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Keywords

  • Multi-cellular aggregates
  • Oncology
  • Shape reconstruction
  • Volume estimation
  • Widefield microscopy

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Computer Science Applications

Cite this

Piccinini, F., Tesei, A., Zoli, W., & Bevilacqua, A. (2015). Image processing method for 3D volume rendering from one 2D projection: Application to Cancer spheroids. In 2014 4th International Conference on Image Processing Theory, Tools and Applications, IPTA 2014 [7001940] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IPTA.2014.7001940