Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review

Grazia Daniela Femminella, Tony Thayanandan, Valeria Calsolaro, Klara Komici, Giuseppe Rengo, Graziamaria Corbi, Nicola Ferrara

Research output: Contribution to journalReview articlepeer-review


Alzheimer's disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer's, as they provide an in vivo window to the pathological processes occurring in Alzheimer's brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer's disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer's research and clinical practice.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Issue number12
Publication statusPublished - Nov 22 2018


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