Imaging and therapy of ovarian cancer: Clinical application of nanoparticles and future perspectives

Research output: Contribution to journalReview article

Abstract

Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treatment for advanced OC relies on the synergistic effect of combining surgical cytoreduction and chemotherapy; however, beside the fact that chemotherapy resistance is a major challenge in OC management, new imaging strategies are needed to target microscopic lesions and improve both cytoreductive surgery and patient outcomes. In this context, nanostructured probes are emerging as a new class of medical tool that can simultaneously provide imaging contrast, target tumor cells, and carry a wide range of medicines resulting in better diagnosis and therapeutic precision. Herein we summarize several exemplary efforts in nanomedicine for addressing unmet clinical needs.

Original languageEnglish
Pages (from-to)4279-4294
Number of pages16
JournalTheranostics
Volume8
Issue number16
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Imaging
  • Nanoparticles
  • Ovarian cancer
  • Surgery
  • Therapy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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