Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: Comparison between MIBG uptake and MR signal intensity ratio

Simone Maurea, Alberto Cuocolo, Massimo Imbriaco, Teresa Pellegrino, Mario Fusari, Renato Cuocolo, Raffaele Liuzzi, Marco Salvatore

Research output: Contribution to journalArticle

Abstract

Objective We compared metaiodobenzylguanidine (MIBG) uptake and magnetic resonance (MR) signal intensity ratio in differentiating benign and malignant disease in patients with pheochromocytoma or paraganglioma. Methods Eighteen patients (9 men, mean age 37 ± 8 years) with pheochromocytoma or paraganglioma underwent MR imaging and iodine-131 MIBG scintigraphy. MR signal intensity ratio was measured on T1 and T2-weighted images using region of interest analysis and intensity ratio of MIBG uptake was calculated for each tumor lesion on 48 h images. Results A total of 28 tumor lesions was analyzed of which 12 were benign and 16 malignant. MIBG uptake intensity ratio was significantly higher in malignant lesions compared to benign (5.2 ± 2.4 and 2.9 ± 1.4, respectively, p

Original languageEnglish
Pages (from-to)670-675
Number of pages6
JournalAnnals of Nuclear Medicine
Volume26
Issue number8
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Benign
  • Malignant
  • MIBG
  • MR
  • Paraganglioma
  • Pheochromocytoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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