Imaging findings in primary central nervous system vasculitis

Giulio Zuccoli, N. Pipitone, A. Haldipur, R. D. Brown, G. Hunder, C. Salvarani

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Primary central nervous system vasculitis (PCNSV) is a rare primary vasculitis limited to the brain and spinal cord. It can affect any age group, but has a predilection for subjects aged 40 to 60 years without clear gender predominance. Clinical manifestations are non-specific, including headache, non-focal neurological features and, less frequently, focal neurological signs. Brain biopsy is the diagnostic gold standard, but may be falsely negative when unaffected tissue is sampled. In addition, brain biopsy carries a small but significant risk of serious complications. Imaging procedures are a key part of the workup of PCNSV patients. They can be used to document the extent and type of lesions, to gauge response to treatment, and sometimes as surrogates for brain biopsy. Magnetic resonance is extremely sensitive but non-specific. The most common findings are multiple bilateral ischaemic lesions often involving white and grey matter. Conventional or magnetic resonance angiography (MRA) typically shows segmental narrowing and dilation in multiple cerebral arteries. However, atypical findings have also been described both with magnetic resonance and angiography. This review discusses the state-of-the-art of current imaging techniques in the workup of PCNSV patients and highlights future prospects.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume29
Issue number1 SUPPL. 64
Publication statusPublished - 2011

Fingerprint

Central Nervous System Vasculitis
Magnetic Resonance Angiography
Brain
Biopsy
Cerebral Arteries
Vasculitis
Headache
Dilatation
Spinal Cord
Magnetic Resonance Spectroscopy
Age Groups

Keywords

  • Adult
  • Central nervous system
  • Cerebral angiography
  • Children
  • Imaging
  • Magnetic resonance
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Zuccoli, G., Pipitone, N., Haldipur, A., Brown, R. D., Hunder, G., & Salvarani, C. (2011). Imaging findings in primary central nervous system vasculitis. Clinical and Experimental Rheumatology, 29(1 SUPPL. 64).

Imaging findings in primary central nervous system vasculitis. / Zuccoli, Giulio; Pipitone, N.; Haldipur, A.; Brown, R. D.; Hunder, G.; Salvarani, C.

In: Clinical and Experimental Rheumatology, Vol. 29, No. 1 SUPPL. 64, 2011.

Research output: Contribution to journalArticle

Zuccoli, G, Pipitone, N, Haldipur, A, Brown, RD, Hunder, G & Salvarani, C 2011, 'Imaging findings in primary central nervous system vasculitis', Clinical and Experimental Rheumatology, vol. 29, no. 1 SUPPL. 64.
Zuccoli G, Pipitone N, Haldipur A, Brown RD, Hunder G, Salvarani C. Imaging findings in primary central nervous system vasculitis. Clinical and Experimental Rheumatology. 2011;29(1 SUPPL. 64).
Zuccoli, Giulio ; Pipitone, N. ; Haldipur, A. ; Brown, R. D. ; Hunder, G. ; Salvarani, C. / Imaging findings in primary central nervous system vasculitis. In: Clinical and Experimental Rheumatology. 2011 ; Vol. 29, No. 1 SUPPL. 64.
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