Imaging HCC treated with radioembolization: review of the literature and clinical examples of choline PET utility

Angelo Castello, Egesta Lopci

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose: In this review we summarize the current evidence on the role of PET/CT with different probes for radioembolization therapy monitoring in HCC patients. Typical clinical examples are also provided to underline the utility of choline PET in this context. Methods: PubMed database was searched from 2000 until March 2020. Results: Overall, 11C-acetate and radiolabeled choline PET have a higher sensitivity in the diagnosis of primary or recurrent HCC as compared to 18F-FDG. On the other hand, 18F-FDG PET/CT can provide useful prognostic information, especially for palliative treatments. Radiolabeled choline better predicts response to loco-regional treatment and provides a better differentiation of disease recurrence from treatment-related changes, as compared to other morphological imaging. Conclusion: HCC staging is better performed with PET/CT, thus allowing for a more adequate selection of patients candidate to transarterial radioembolization.

Original languageEnglish
Pages (from-to)377-392
Number of pages16
JournalClinical and Translational Imaging
Volume8
Issue number5
DOIs
Publication statusPublished - Oct 1 2020

Keywords

  • 11C-acetate
  • 11C-choline
  • 18F-FDG
  • 18F-fluorocholine
  • 18F-fluoroethylcholine
  • PET/CT
  • Radioembolization
  • TARE

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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