TY - JOUR
T1 - Imaging in nasopharyngeal carcinoma
T2 - The value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI
AU - Nordin, Abdul Jalil
AU - Secondino, Simona
AU - Rahim, Noraini Abdul
AU - Pedrazzoli, Paolo
AU - Siena, Salvatore
AU - Rossetti, Claudio
AU - Aris, Tahir
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Background. The aim of the study was to evaluate the clinical usefulness of 18F Fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) in the management of nasopharyngeal carcinoma (NPC) in comparison to conventional imaging modalities.Methods. This retrospective study was done at Ospedale Niguarda, Milan, Italy. Data were acquired from 24 NPC patients between May 2003 and December 2006. They had FDG PET/CT and CT or MRI during the initial diagnosis and at follow-up. Each finding was tabulated and compared with tissue biopsy at diagnosis and clinical status during the follow up after the therapy. A statistical calculation was done to derive the value of each modality.Results. The sensitivity and accuracy of PET/CT and CT/MRI were equally high at diagnosis. At the follow up, a negative PET/CT finding suggested a complete remission with sensitivity and negative predictive value of 100%.Conclusions. 18F FDG PET/CT is a potential modality to be utilized in following up NPC patients for evaluating a response to therapy.
AB - Background. The aim of the study was to evaluate the clinical usefulness of 18F Fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) in the management of nasopharyngeal carcinoma (NPC) in comparison to conventional imaging modalities.Methods. This retrospective study was done at Ospedale Niguarda, Milan, Italy. Data were acquired from 24 NPC patients between May 2003 and December 2006. They had FDG PET/CT and CT or MRI during the initial diagnosis and at follow-up. Each finding was tabulated and compared with tissue biopsy at diagnosis and clinical status during the follow up after the therapy. A statistical calculation was done to derive the value of each modality.Results. The sensitivity and accuracy of PET/CT and CT/MRI were equally high at diagnosis. At the follow up, a negative PET/CT finding suggested a complete remission with sensitivity and negative predictive value of 100%.Conclusions. 18F FDG PET/CT is a potential modality to be utilized in following up NPC patients for evaluating a response to therapy.
KW - Computed tomography
KW - Follow-up
KW - Magnetic resonance imaging
KW - Nasopharyngeal carcinoma
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=71049147950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71049147950&partnerID=8YFLogxK
U2 - 10.2478/v10019-009-0026-8
DO - 10.2478/v10019-009-0026-8
M3 - Article
AN - SCOPUS:71049147950
VL - 43
SP - 247
EP - 257
JO - Radiology and Oncology
JF - Radiology and Oncology
SN - 1318-2099
IS - 4
ER -