Imaging neuroinflammation in ischemic stroke and in the atherosclerotic vascular disease

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neuroinflammation is a complex biological response to any injury occurring to the central nervous system. It is mainly characterized by the recruitment of immune system cells, namely the microglial cells, in the site of injury. Once activated, microglia expresses a cholesterol transporter protein (TSPO), previously also known as peripheral type benzodiazepine receptor. PK11195 is a ligand for TSPO and, labelled with a positron emitter, it is also the most used tracer for PET molecular imaging to in vivo map the microglia activation in various neurological disorders, including ischemic stroke. Recent [11C]PK11195 PET studies proved activated microglia both locally in the area of the infarct and at distance along the affected fibre tracts, suggesting the presence of two different microglia subtypes with peculiar functions in disease progression. The aim of this review is to discuss the most recent knowledge about imaging neuroinflammation in ischemic stroke and in the atherosclerotic and vascular inflammatory disorders, trying to elucidate the interplay between the clinical course and the activation of a microglial response.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalCurrent Vascular Pharmacology
Volume13
Issue number2
Publication statusPublished - May 1 2015

Fingerprint

Microglia
Vascular Diseases
Stroke
Molecular Imaging
Wounds and Injuries
GABA-A Receptors
Nervous System Diseases
Blood Vessels
Disease Progression
Immune System
Proteins
Central Nervous System
Cholesterol
Electrons
Ligands

Keywords

  • Activated microglia
  • Ischemic stroke
  • Neuroinflammation
  • PET imaging
  • [<sup>11</sup>C]PK11195

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Imaging neuroinflammation in ischemic stroke and in the atherosclerotic vascular disease. / Cerami, Chiara; Perani, Daniela.

In: Current Vascular Pharmacology, Vol. 13, No. 2, 01.05.2015, p. 218-222.

Research output: Contribution to journalArticle

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