Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy

Vanina Vani, Daniele Regge, Giovanni Cappello, Michela Gabelloni, Emanuele Neri

Research output: Contribution to journalReview articlepeer-review


Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related adverse events (irAEs). IrAEs may affect any organ or apparatus and most frequently involve skin, colon, endocrine organs, liver, and lungs. Early identification and appropriate treatment of irAEs can improve patient outcome. The paper aims at reviewing mechanisms of the occurrence of irAEs, the importance of a proper diagnosis and the main pillars of therapy. To provide effective guidance to the comprehension of major irAEs imaging findings will be reviewed.

Original languageEnglish
Issue number4
Publication statusPublished - Apr 13 2020


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