Imaging of diabetic bone

Federico Ponti, Sara Guerri, Claudia Sassi, Giuseppe Battista, Giuseppe Guglielmi, Alberto Bazzocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes is an important concern in terms of medical and socioeconomic costs; a high risk for low-trauma fractures has been reported in patients with both type 1 and type 2 diabetes. The mechanism involved in the increased fracture risk from diabetes is highly complex and still not entirely understood; obesity could play an important role: recent evidence suggests that the influence of fat on bone is mainly dependent on the pattern of regional fat deposition and that an increased amount of visceral adipose tissue negatively affects skeletal health. Correct and timely individuation of people with high fracture risk is critical for both prevention and treatment: Dual-energy X-ray Absorptiometry (currently the “gold standard” for diagnosis of osteoporosis) underestimates fracture risk in diabetic patients and therefore is not sufficient by itself to investigate bone status. This paper is focused on imaging, covering different modalities involved in the evaluation of skeletal deterioration in diabetes, discussing the limitations of conventional methods and exploring the potential of new tools and recent high-resolution techniques, with the intent to provide interesting insight into pathophysiology and fracture risk.

Original languageEnglish
Pages (from-to)426-441
Number of pages16
JournalEndocrine
Volume58
Issue number3
DOIs
Publication statusAccepted/In press - Mar 14 2017

Keywords

  • Absorptiometry, photon
  • Bone fractures
  • Bone microarchitecture
  • Bone mineral density
  • Diabetes mellitus
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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