Imaging of myocardial receptors: Applications in the evaluation of cardiac disease

Ornella Rimoldi, Paolo G. Camici

Research output: Contribution to journalArticle

Abstract

Several positron labelled radiopharmaceuticals have been used to assess cardiac neurotransmission both at presynaptic and postsynaptic level. Some tracers compete with endogenous noradrenaline for the transport into the presynaptic nerve terminal mainly via the neuronal uptake-1 transport system. Several beta-blocking drugs have been labelled with 11C to act as radioligands for imaging the study of postsynaptic receptors by PET. The most extensively used is 11C-(S)-CGP 12177. This is a non-selective b-adrenoceptor antagonist with high affinity and low lipophilicity. Studies in patients have demonstrated diffuse down-regulation of β-adrenoceptor density in hypertrophic cardiomyopathy and in congestive heart cardiac failure, two disorders where there is evidence of elevated levels of sympathetic activation.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalHeart and Metabolism
Issue number41
Publication statusPublished - 2008

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Keywords

  • Alpha adrenergic receptor
  • Beta adrenergic receptor
  • Cardiomyopathy
  • Heart failure
  • PET

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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