Imaging of neuroendocrine gastro-entero-pancreatic tumours using radiolabelled somatostatin analogues

A. Chiti, B. J. Van Graafeiland, G. Savelli, L. Ferrari, E. Seregni, M. R. Castellani, E. Bombardieri

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine tumours of the gastro-entero-pancreatic tract are an uncommon clinical entity and are believed to arise from the endocrine cells of the gastrointestinal tract. Somatostatin receptor imaging is a diagnostic tool which allows visualization of somatostatin receptor bearing tumours. This scintigraphic procedure is performed with indium-111 labelled octreotide, a somatostatin analogue, chelated with diethylene triamine penta-acetic acid. Radionuclide imaging consists in detecting the biodistribution of somatostatin receptors, normally expressed on the cell surface of neuroendocrine gastro-entero-pancreatic tumours. To date, five types of this receptor have been cloned; indium-111-labelled-pentetreotide can visualize tumours expressing type 2 and 5 receptors. The results of our study, which involved 81 neuroendocrine gastro-entero-pancreatic tumour patients, confirm the superior sensitivity of somatostatin receptor imaging (61%) for primary tumour evaluation with respect to conventional imaging modalities such as computed tomography (40%) or ultrasound (28%). Scintigraphic findings in metastatic liver disease proved to have a sensitivity of 89% for somatostatin receptor imaging, versus 81% and 88% for computed tomography and ultrasound, respectively. In 23% of patients, lesions were found with somatostatin receptor imaging which had been missed using the other diagnostic modalities; in 26% of the patients the therapeutic approach was modified after somatostatin receptor imaging.

Original languageEnglish
JournalItalian Journal of Gastroenterology and Hepatology
Volume31
Issue number7 SUPPL. 2
Publication statusPublished - 1999

Keywords

  • Neuroendocrine tumours
  • Single photon emission tomography
  • Somatostatin receptor scintigraphy

ASJC Scopus subject areas

  • Gastroenterology

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