Imaging of the parathyroid glands in primary hyperparathyroidism

Salvatore Minisola, Cristiana Cipriani, Daniele Diacinti, Francesco Tartaglia, Alfredo Scillitani, Jessica Pepe, David Scott-Coombes

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Primary hyperparathyroidism (PHPT) is one of the most frequent endocrine diseases worldwide. Surgery is the only potentially curable option for patients with this disorder, even though in asymptomatic patients 50 years of age or older without end organ complications, a conservative treatment may be a possible alternative. Bilateral neck exploration under general anaesthesia has been the standard for the definitive treatment. However, significant improvements in preoperative imaging, together with the implementation of rapid parathyroid hormone determination, have determined an increased implementation of focused, minimally invasive surgical approach. Surgeons prefer to have a localization study before an operation (both in the classical scenario and in the minimally invasive procedure). They are not satisfied by having been referred a patient with just a biochemical diagnosis of PHPT. Imaging studies must not be utilized to make the diagnosis of PHPT. They should be obtained to both assist in determining disease etiology and to guide operative procedures together with the nuclear medicine doctor and, most importantly, with the surgeon. On the contrary, apart from minimally invasive procedures in which localization procedures are an obligate choice, some surgeons believe that literature on parathyroidectomy over the past two decades reveals a bias towards localization. Therefore, surgical expertise is more important than the search for abnormal parathyroid glands.

Original languageEnglish
Pages (from-to)D1-D8
JournalEuropean Journal of Endocrinology
Volume174
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Parathyroid Glands
Primary Hyperparathyroidism
Endocrine System Diseases
Parathyroidectomy
Nuclear Medicine
Operative Surgical Procedures
Parathyroid Hormone
General Anesthesia
Neck
Surgeons
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Minisola, S., Cipriani, C., Diacinti, D., Tartaglia, F., Scillitani, A., Pepe, J., & Scott-Coombes, D. (2016). Imaging of the parathyroid glands in primary hyperparathyroidism. European Journal of Endocrinology, 174(1), D1-D8. https://doi.org/10.1530/EJE-15-0565

Imaging of the parathyroid glands in primary hyperparathyroidism. / Minisola, Salvatore; Cipriani, Cristiana; Diacinti, Daniele; Tartaglia, Francesco; Scillitani, Alfredo; Pepe, Jessica; Scott-Coombes, David.

In: European Journal of Endocrinology, Vol. 174, No. 1, 01.01.2016, p. D1-D8.

Research output: Contribution to journalArticle

Minisola, S, Cipriani, C, Diacinti, D, Tartaglia, F, Scillitani, A, Pepe, J & Scott-Coombes, D 2016, 'Imaging of the parathyroid glands in primary hyperparathyroidism', European Journal of Endocrinology, vol. 174, no. 1, pp. D1-D8. https://doi.org/10.1530/EJE-15-0565
Minisola, Salvatore ; Cipriani, Cristiana ; Diacinti, Daniele ; Tartaglia, Francesco ; Scillitani, Alfredo ; Pepe, Jessica ; Scott-Coombes, David. / Imaging of the parathyroid glands in primary hyperparathyroidism. In: European Journal of Endocrinology. 2016 ; Vol. 174, No. 1. pp. D1-D8.
@article{9fa66b5930f84e1094f8ae98130145f9,
title = "Imaging of the parathyroid glands in primary hyperparathyroidism",
abstract = "Primary hyperparathyroidism (PHPT) is one of the most frequent endocrine diseases worldwide. Surgery is the only potentially curable option for patients with this disorder, even though in asymptomatic patients 50 years of age or older without end organ complications, a conservative treatment may be a possible alternative. Bilateral neck exploration under general anaesthesia has been the standard for the definitive treatment. However, significant improvements in preoperative imaging, together with the implementation of rapid parathyroid hormone determination, have determined an increased implementation of focused, minimally invasive surgical approach. Surgeons prefer to have a localization study before an operation (both in the classical scenario and in the minimally invasive procedure). They are not satisfied by having been referred a patient with just a biochemical diagnosis of PHPT. Imaging studies must not be utilized to make the diagnosis of PHPT. They should be obtained to both assist in determining disease etiology and to guide operative procedures together with the nuclear medicine doctor and, most importantly, with the surgeon. On the contrary, apart from minimally invasive procedures in which localization procedures are an obligate choice, some surgeons believe that literature on parathyroidectomy over the past two decades reveals a bias towards localization. Therefore, surgical expertise is more important than the search for abnormal parathyroid glands.",
author = "Salvatore Minisola and Cristiana Cipriani and Daniele Diacinti and Francesco Tartaglia and Alfredo Scillitani and Jessica Pepe and David Scott-Coombes",
year = "2016",
month = "1",
day = "1",
doi = "10.1530/EJE-15-0565",
language = "English",
volume = "174",
pages = "D1--D8",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "1",

}

TY - JOUR

T1 - Imaging of the parathyroid glands in primary hyperparathyroidism

AU - Minisola, Salvatore

AU - Cipriani, Cristiana

AU - Diacinti, Daniele

AU - Tartaglia, Francesco

AU - Scillitani, Alfredo

AU - Pepe, Jessica

AU - Scott-Coombes, David

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Primary hyperparathyroidism (PHPT) is one of the most frequent endocrine diseases worldwide. Surgery is the only potentially curable option for patients with this disorder, even though in asymptomatic patients 50 years of age or older without end organ complications, a conservative treatment may be a possible alternative. Bilateral neck exploration under general anaesthesia has been the standard for the definitive treatment. However, significant improvements in preoperative imaging, together with the implementation of rapid parathyroid hormone determination, have determined an increased implementation of focused, minimally invasive surgical approach. Surgeons prefer to have a localization study before an operation (both in the classical scenario and in the minimally invasive procedure). They are not satisfied by having been referred a patient with just a biochemical diagnosis of PHPT. Imaging studies must not be utilized to make the diagnosis of PHPT. They should be obtained to both assist in determining disease etiology and to guide operative procedures together with the nuclear medicine doctor and, most importantly, with the surgeon. On the contrary, apart from minimally invasive procedures in which localization procedures are an obligate choice, some surgeons believe that literature on parathyroidectomy over the past two decades reveals a bias towards localization. Therefore, surgical expertise is more important than the search for abnormal parathyroid glands.

AB - Primary hyperparathyroidism (PHPT) is one of the most frequent endocrine diseases worldwide. Surgery is the only potentially curable option for patients with this disorder, even though in asymptomatic patients 50 years of age or older without end organ complications, a conservative treatment may be a possible alternative. Bilateral neck exploration under general anaesthesia has been the standard for the definitive treatment. However, significant improvements in preoperative imaging, together with the implementation of rapid parathyroid hormone determination, have determined an increased implementation of focused, minimally invasive surgical approach. Surgeons prefer to have a localization study before an operation (both in the classical scenario and in the minimally invasive procedure). They are not satisfied by having been referred a patient with just a biochemical diagnosis of PHPT. Imaging studies must not be utilized to make the diagnosis of PHPT. They should be obtained to both assist in determining disease etiology and to guide operative procedures together with the nuclear medicine doctor and, most importantly, with the surgeon. On the contrary, apart from minimally invasive procedures in which localization procedures are an obligate choice, some surgeons believe that literature on parathyroidectomy over the past two decades reveals a bias towards localization. Therefore, surgical expertise is more important than the search for abnormal parathyroid glands.

UR - http://www.scopus.com/inward/record.url?scp=84956822444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956822444&partnerID=8YFLogxK

U2 - 10.1530/EJE-15-0565

DO - 10.1530/EJE-15-0565

M3 - Article

C2 - 26340967

AN - SCOPUS:84956822444

VL - 174

SP - D1-D8

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 1

ER -