Imaging T-cell movement in the brain during experimental cerebral malaria: Brief Definitive Report

F. Ortolano, P. Maffia, G. Dever, S. Hutchison, R. Benson, O. R. Millington, M. G. De Simoni, T. J. Bushell, P. Garside, H. V. Carswell, J. M. Brewer

Research output: Contribution to journalArticle

Abstract

T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalParasite Immunology
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2009

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Cerebral Malaria
Cell Movement
Pathology
T-Lymphocytes
Host-Parasite Interactions
Brain
Confocal Microscopy

Keywords

  • Brain
  • ECM.
  • Imaging
  • In vivo
  • Microscopy
  • Plasmodium
  • T lymphocytes

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Ortolano, F., Maffia, P., Dever, G., Hutchison, S., Benson, R., Millington, O. R., ... Brewer, J. M. (2009). Imaging T-cell movement in the brain during experimental cerebral malaria: Brief Definitive Report. Parasite Immunology, 31(3), 147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x

Imaging T-cell movement in the brain during experimental cerebral malaria : Brief Definitive Report. / Ortolano, F.; Maffia, P.; Dever, G.; Hutchison, S.; Benson, R.; Millington, O. R.; De Simoni, M. G.; Bushell, T. J.; Garside, P.; Carswell, H. V.; Brewer, J. M.

In: Parasite Immunology, Vol. 31, No. 3, 03.2009, p. 147-150.

Research output: Contribution to journalArticle

Ortolano, F, Maffia, P, Dever, G, Hutchison, S, Benson, R, Millington, OR, De Simoni, MG, Bushell, TJ, Garside, P, Carswell, HV & Brewer, JM 2009, 'Imaging T-cell movement in the brain during experimental cerebral malaria: Brief Definitive Report', Parasite Immunology, vol. 31, no. 3, pp. 147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x
Ortolano, F. ; Maffia, P. ; Dever, G. ; Hutchison, S. ; Benson, R. ; Millington, O. R. ; De Simoni, M. G. ; Bushell, T. J. ; Garside, P. ; Carswell, H. V. ; Brewer, J. M. / Imaging T-cell movement in the brain during experimental cerebral malaria : Brief Definitive Report. In: Parasite Immunology. 2009 ; Vol. 31, No. 3. pp. 147-150.
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