Imaging the optic nerve in multiple sclerosis

M. A. Rocca, S. J. Hickman, L. Bö, F. Agosta, D. H. Miller, G. Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


Although multiple sclerosis (MS) frequently involves the optic nerves, imaging this structure is not yet performed routinely in clinical practice. The recent improvement of magnetic resonance (MR) technology and the development of new MR strategies, capable of providing an, in vivo, overall assessment of MS pathology has allowed objective metrics to be obtained for monitoring disease evolution, essentially in the brain. However, despite this progress, the correlation between brain MR metrics of the disease and clinical disability are still disappointing. An objective and accurate estimate of the presence and extent of optic nerve involvement might help to overcome this clinical/MRI paradox. This review summarizes the main results obtained from the application of conventional and modern MR-based techniques for the evaluation of optic nerve damage in MS.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalMultiple Sclerosis Journal
Issue number5
Publication statusPublished - Oct 2005


  • Disability
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Optic nerve
  • Pathology

ASJC Scopus subject areas

  • Clinical Neurology


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